Dicycloverine
 | |
| Systematic (IUPAC) name | |
|---|---|
|
2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate | |
| Clinical data | |
| Trade names | Byclomine, Bentyl, Dibent, Di-Spaz, Dilomine |
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a684007 |
| Pregnancy category | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | >99% |
| Biological half-life | 5 h |
| Identifiers | |
| CAS Number |
77-19-0  |
| ATC code | A03AA07 (WHO) |
| PubChem | CID 3042 |
| IUPHAR/BPS | 355 |
| DrugBank |
DB00804 |
| ChemSpider |
2934 |
| UNII |
4KV4X8IF6V |
| KEGG |
D07820 |
| ChEBI |
CHEBI:4514 |
| ChEMBL |
CHEMBL1123 |
| Chemical data | |
| Formula | C19H35NO2 |
| Molar mass | 309.487 g/mol |
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Dicycloverine, also known as dicyclomine, is an anticholinergic that blocks muscarinic receptors. Dicycloverine was first synthesized in the United States circa 1947.[1]
Medical uses
A 10-mg oral capsule of dicyclomine hydrochloride, manufactured by Mylan
Dicyclomine is used to treat intestinal hypermotility and the symptoms of irritable bowel syndrome (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.[2]
In the UK, it is an ingredient of a multiple-ingredient preparation, with an antiflatulent (simethicone) and two antacids, under the trade name Kolanticon. In India, it is of a compound with paracetamol under the trade name Cyclopam. It is also marketed as Meftal-SPAS containing mefenamic acid along with dicyclomine hydrochloride as an analgesic and antispasmodic. Also it is a part of Normaxin containing two other salts clidinium bromide and chlordiazepoxide.
Side effects
Dicyclomine can cause a range of anticholinergic side effects such as dry mouth, nausea, and, at higher doses, deliriant effects.[2] Recreational use of this drug for its anticholinergic effects (both low dose for euphoria and high dose for delirium) has been rarely reported.
Caution
Breastfeeding is not recommended while using this drug. Users should use care when operating vehicles and/or dangerous machines.[2]
See also
- Adiphenine (Similar design except that both cyclohexane groups now unsaturated so that they become phenyl groups).
References
- ↑ Tilford, C. H.; Campen, M. G. V.; Shelton, R. S. (1947). "Aminoesters of Substituted Alicylic Carboxylic Acids1". Journal of the American Chemical Society 69 (11): 2902. doi:10.1021/ja01203a077.
- 1 2 3 "Dicyclomine hydrochloride". Monograph. Drugs.com.
Further reading
- Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
- Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4
External links
- "Dicyclomine". Medicine Net.
- "Dicyclomine". Medline Plus.
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