Cellulose synthase (GDP-forming)

cellulose synthase (GDP-forming)
Identifiers
EC number	2.4.1.29
CAS number	9027-18-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a cellulose synthase (GDP-forming) (EC 2.4.1.29) is an enzyme that catalyzes the chemical reaction

GDP-glucose + (1,4-beta-D-glucosyl)n $\rightleftharpoons$ GDP + (1,4-beta-D-glucosyl)n⁺1

Thus, the two substrates of this enzyme are GDP-glucose and (1,4-beta-D-glucosyl)n, whereas its two products are GDP and (1,4-beta-D-glucosyl)n+1.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase. Other names in common use include cellulose synthase (guanosine diphosphate-forming), cellulose synthetase, guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase, and guanosine diphosphoglucose-cellulose glucosyltransferase. This enzyme participates in starch and sucrose metabolism.

References

• Chambers J, Elbein AD (1970). "Biosynthesis of glucans in mung bean seedlings. Formation of beta-(1,4)-glucans from GDP-glucose and beta-(1,3)-glucans from UDP-glucose". Arch. Biochem. Biophys. 138 (2): 620–31. doi:10.1016/0003-9861(70)90389-9. PMID 4317490.
• Flowers HM, Batra KK, Kemp J, Hassid WZ (1969). "Biosynthesis of cellulose in vitro from guanosine diphosphate D-glucose with enzymic preparations from Phaseolus aureus and Lupinus albus". J. Biol. Chem. 244 (18): 4969–74. PMID 5824571.