Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase

Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
Identifiers
EC number 2.4.99.12
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Lipid IVA 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.12, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase, lipid IVA KDO transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

lipid IVA + CMP-alpha-Kdo \rightleftharpoons alpha-Kdo-(2->6)-lipid IVA + CMP

The bifunctional enzyme from Escherichia coli transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA.

See also

References

  1. ↑ Belunis, C.J. and Raetz, C.R. (1992). "Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli". J. Biol. Chem. 267 (14): 9988–9997. PMID 1577828.
  2. ↑ Mamat, U., Schmidt, H., Munoz, E., Lindner, B., Fukase, K., Hanuszkiewicz, A., Wu, J., Meredith, T.C., Woodard, R.W., Hilgenfeld, R., Mesters, J.R. and Holst, O. (2009). "WaaA of the hyperthermophilic bacterium Aquifex aeolicus is a monofunctional 3-deoxy-D-manno-oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesis". J. Biol. Chem. 284 (33): 22248–22262. doi:10.1074/jbc.M109.033308. PMC 2755949. PMID 19546212.
  3. ↑ White, K.A., Kaltashov, I.A., Cotter, R.J. and Raetz, C.R. (1997). "A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae". J. Biol. Chem. 272 (26): 16555–16563. doi:10.1074/jbc.272.26.16555. PMID 9195966.
  4. ↑ Lobau, S., Mamat, U., Brabetz, W. and Brade, H. (1995). "Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183". Mol. Microbiol. 18 (3): 391–399. doi:10.1111/j.1365-2958.1995.mmi_18030391.x. PMID 8748024.

External links

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