Ephrin A4

Ephrin-A4
Identifiers
Symbols	EFNA4 ; EFL4; EPLG4; LERK4
External IDs	OMIM: 601380 MGI: 106643 HomoloGene: 3830 GeneCards: EFNA4 Gene
Gene ontology Molecular function • transmembrane-ephrin receptor activity • protein binding • ephrin receptor binding Cellular component • extracellular region • plasma membrane • integral component of plasma membrane • anchored component of membrane Biological process • cell-cell signaling • axon guidance • osteoclast differentiation • bone remodeling • ephrin receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1945	13639
Ensembl	ENSG00000243364	ENSMUSG00000028040
UniProt	P52798	O08542
RefSeq (mRNA)	NM_005227	NM_007910
RefSeq (protein)	NP_005218	NP_031936
Location (UCSC)	Chr 1: 155.06 – 155.07 Mb	Chr 3: 89.33 – 89.34 Mb
PubMed search

Ephrin A4 is a protein that in humans is encoded by the EFNA4 gene.^[1][2]

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.^[2]

References

1. Cerretti DP, Lyman SD, Kozlosky CJ, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW (Jan 1997). "The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3". Genomics 33 (2): 277–82. doi:10.1006/geno.1996.0192. PMID 8660976.
2. "Entrez Gene: EFNA4 ephrin-A4".

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development 126 (10): 2033–44. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216. |chapter= ignored (help)
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
• Kozlosky CJ, Maraskovsky E, McGrew JT; et al. (1995). "Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins". Oncogene 10 (2): 299–306. PMID 7838529.
• Gale NW, Holland SJ, Valenzuela DM; et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474.
• Ephnomenclaturecommittee, (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
• Janis LS, Cassidy RM, Kromer LF (1999). "Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum". J. Neurosci. 19 (12): 4962–71. PMID 10366629.
• Choi S, Jeong J, Kim T, Park S (2000). "Characterization of ephrin-A1 and ephrin-A4 as ligands for the EphA8 receptor protein tyrosine kinase". Mol. Cells 9 (4): 440–5. PMID 10515610.
• Aasheim HC, Munthe E, Funderud S; et al. (2000). "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes". Blood 95 (1): 221–30. PMID 10607706.
• Munthe E, Aasheim HC (2002). "Characterization of the human ephrin-A4 promoter". Biochem. J. 366 (Pt 2): 447–58. doi:10.1042/BJ20011693. PMC 1222801. PMID 12030849.