Endothelin 3

Endothelin 3
Identifiers
Symbols	EDN3 ; ET-3; ET3; HSCR4; PPET3; WS4B
External IDs	OMIM: 131242 MGI: 95285 HomoloGene: 88 GeneCards: EDN3 Gene
Gene ontology Molecular function • receptor binding • hormone activity Cellular component • extracellular region • extracellular space • intracellular • cell Biological process • neural crest cell migration • positive regulation of leukocyte chemotaxis • regulation of systemic arterial blood pressure by endothelin • cellular calcium ion homeostasis • signal transduction • cell surface receptor signaling pathway • cell-cell signaling • multicellular organismal development • blood circulation • positive regulation of cell proliferation • positive regulation of heart rate • regulation of gene expression • cellular magnesium ion homeostasis • artery smooth muscle contraction • vein smooth muscle contraction • regulation of vasoconstriction • peptide hormone secretion • neuron differentiation • melanocyte differentiation • neutrophil chemotaxis • vasoconstriction • positive regulation of MAP kinase activity • positive regulation of cell differentiation • positive regulation of mitotic nuclear division • positive regulation of hormone secretion • inositol phosphate-mediated signaling • regulation of developmental pigmentation • positive regulation of potassium ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1908	13616
Ensembl	ENSG00000124205	ENSMUSG00000027524
UniProt	P14138	P48299
RefSeq (mRNA)	NM_000114	NM_007903
RefSeq (protein)	NP_001289384	NP_031929
Location (UCSC)	Chr 20: 59.3 – 59.33 Mb	Chr 2: 174.76 – 174.78 Mb
PubMed search

Endothelin-3 is a protein that in humans is encoded by the EDN3 gene.^[1]

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.^[1]

References

1. "Entrez Gene: EDN3 endothelin 3".

Further reading

• Calderone RA (1994). "Molecular interactions at the interface of Candida albicans and host cells.". Arch. Med. Res. 24 (3): 275–9. PMID 8298278.
• Hofstra RM, Osinga J, Buys CH (1998). "Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype.". Eur. J. Hum. Genet. 5 (4): 180–5. PMID 9359036.
• Parisi MA, Kapur RP (2001). "Genetics of Hirschsprung disease.". Curr. Opin. Pediatr. 12 (6): 610–7. doi:10.1097/00008480-200012000-00017. PMID 11106284.
• O'Reilly G, Charnock-Jones DS, Davenport AP; et al. (1993). "Presence of messenger ribonucleic acid for endothelin-1, endothelin-2, and endothelin-3 in human endometrium and a change in the ratio of ETA and ETB receptor subtype across the menstrual cycle.". J. Clin. Endocrinol. Metab. 75 (6): 1545–9. doi:10.1210/jc.75.6.1545. PMID 1464662.
• Mills RG, O'Donoghue SI, Smith R, King GF (1992). "Solution structure of endothelin-3 determined using NMR spectroscopy.". Biochemistry 31 (24): 5640–5. doi:10.1021/bi00139a030. PMID 1610811.
• Rao VV, Löffler C, Hansmann I (1991). "The gene for the novel vasoactive peptide endothelin 3 (EDN3) is localized to human chromosome 20q13.2-qter.". Genomics 10 (3): 840–1. doi:10.1016/0888-7543(91)90472-Q. PMID 1889823.
• Arinami T, Ishikawa M, Inoue A; et al. (1991). "Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin-2 gene (EDN2) to 1p34, and the endothelin-3 gene (EDN3) to 20q13.2-q13.3.". Am. J. Hum. Genet. 48 (5): 990–6. PMC 1683044. PMID 2018043.
• Onda H, Ohkubo S, Ogi K; et al. (1990). "One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta.". FEBS Lett. 261 (2): 327–30. doi:10.1016/0014-5793(90)80583-5. PMID 2178974.
• Lees WE, Kalinka S, Meech J; et al. (1990). "Generation of human endothelin by cathepsin E.". FEBS Lett. 273 (1–2): 99–102. doi:10.1016/0014-5793(90)81060-2. PMID 2226872.
• Bloch KD, Eddy RL, Shows TB, Quertermous T (1989). "cDNA cloning and chromosomal assignment of the gene encoding endothelin 3". J. Biol. Chem. 264 (30): 18156–61. PMID 2509452.
• Inoue A, Yanagisawa M, Kimura S; et al. (1989). "The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2863–7. doi:10.1073/pnas.86.8.2863. PMC 287019. PMID 2649896.
• Yu JC, Davenport AP (1995). "Secretion of endothelin-1 and endothelin-3 by human cultured vascular smooth muscle cells". Br. J. Pharmacol. 114 (2): 551–7. doi:10.1111/j.1476-5381.1995.tb13262.x. PMC 1510231. PMID 7881755.
• Baynash AG, Hosoda K, Giaid A; et al. (1995). "Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons". Cell 79 (7): 1277–85. doi:10.1016/0092-8674(94)90018-3. PMID 8001160.
• Edery P, Attié T, Amiel J; et al. (1996). "Mutation of the endothelin-3 gene in the Waardenburg-Hirschsprung disease (Shah-Waardenburg syndrome)". Nat. Genet. 12 (4): 442–4. doi:10.1038/ng0496-442. PMID 8630502.
• Hofstra RM, Osinga J, Tan-Sindhunata G; et al. (1996). "A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome)". Nat. Genet. 12 (4): 445–7. doi:10.1038/ng0496-445. PMID 8630503.
• Lahav R, Ziller C, Dupin E, Le Douarin NM (1996). "Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture". Proc. Natl. Acad. Sci. U.S.A. 93 (9): 3892–7. doi:10.1073/pnas.93.9.3892. PMC 39455. PMID 8632985.
• Bolk S, Angrist M, Xie J; et al. (1996). "Endothelin-3 frameshift mutation in congenital central hypoventilation syndrome". Nat. Genet. 13 (4): 395–6. doi:10.1038/ng0896-395. PMID 8696331.
• Nakano A, Kishi F, Minami K; et al. (1997). "Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase from human mast cells". J. Immunol. 159 (4): 1987–92. PMID 9257865.
• Bourgeois C, Robert B, Rebourcet R; et al. (1997). "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3". J. Clin. Endocrinol. Metab. 82 (9): 3116–23. doi:10.1210/jc.82.9.3116. PMID 9284755.
• Wiesmann F, Veeck J, Galm O; et al. (2009). "Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer". Breast Cancer Res. 11 (3): R34. doi:10.1186/bcr2319. PMC 2716502. PMID 19527488.