TLL1

Tolloid-like 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3EDI​
Identifiers
Symbols	TLL1 ; ASD6; TLL
External IDs	OMIM: 606742 MGI: 106923 HomoloGene: 49202 GeneCards: TLL1 Gene
EC number	3.4.24.-
Gene ontology Molecular function • metalloendopeptidase activity • calcium ion binding • collagen binding • zinc ion binding Cellular component • extracellular region Biological process • skeletal system development • proteolysis • extracellular matrix disassembly • cell differentiation • extracellular matrix organization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7092	21892
Ensembl	ENSG00000038295	ENSMUSG00000053626
UniProt	O43897	Q62381
RefSeq (mRNA)	NM_001204760	NM_009390
RefSeq (protein)	NP_001191689	NP_033416
Location (UCSC)	Chr 4: 165.87 – 166.1 Mb	Chr 8: 64.01 – 64.21 Mb
PubMed search

Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.^[1][2]

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites.^[2]

References

1. Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19". Cytogenet Cell Genet 86 (1): 64–5. doi:10.1159/000015412. PMID 10516436.
2. "Entrez Gene: TLL1 tolloid-like 1".

Further reading

• Takahara K, Brevard R, Hoffman GG, et al. (1997). "Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1.". Genomics 34 (2): 157–65. doi:10.1006/geno.1996.0260. PMID 8661043.
• Scott IC, Blitz IL, Pappano WN, et al. (1999). "Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.". Dev. Biol. 213 (2): 283–300. doi:10.1006/dbio.1999.9383. PMID 10479448.
• Scott IC, Imamura Y, Pappano WN, et al. (2000). "Bone morphogenetic protein-1 processes probiglycan.". J. Biol. Chem. 275 (39): 30504–11. doi:10.1074/jbc.M004846200. PMID 10896944.
• Uzel MI, Scott IC, Babakhanlou-Chase H, et al. (2001). "Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures.". J. Biol. Chem. 276 (25): 22537–43. doi:10.1074/jbc.M102352200. PMID 11313359.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ge G, Zhang Y, Steiglitz BM, Greenspan DS (2006). "Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains.". J. Biol. Chem. 281 (16): 10786–98. doi:10.1074/jbc.M511111200. PMID 16507574.