Etazocine

Etazocine

Systematic (IUPAC) name
1,2,3,4,5,6-hexahydro-6,11-diethyl-3-methyl-2,6-methano-3-benzazocin-8-ol or 5,7-diethyl-2-hydroxy-2-methyl-6,7-benzomorphan
Clinical data
Legal status	Non-regulated
Identifiers
CAS Number	34254-87-0 10286-45-0 ((−)-form (HCl))
ATC code	None
PubChem	CID 187767
ChemSpider	163214
Synonyms	NIH-7856 ((±)-form); GPA-208 ((−)-form); GPA-2087 ((−)-form); NIH-8178 ((−)-form); FDA-0487 ((−)-form)
Chemical data
Formula	C17H25NO
Molar mass	259.387 g/mol
SMILES Oc1ccc3c(c1)[C@@]2([C@H]([C@@H](N(CC2)C)C3)CC)CC
InChI InChI=1S/C17H25NO/c1-4-14-16-10-12-6-7-13(19)11-15(12)17(14,5-2)8-9-18(16)3/h6-7,11,14,16,19H,4-5,8-10H2,1-3H3/t14-,16-,17-/m0/s1 Key:JYRBQCWXZNDERM-XIRDDKMYSA-N

Etazocine (NIH-7856) is an opioid analgesic of the benzomorphan family which was never marketed.^[1][2] It acts as a partial agonist of the opioid receptors, with mixed agonist and antagonist effects.^[1] In animal studies, it was shown to induce analgesia, dependency, and respiratory depression, with overall effects similar to those of morphine, but with substantially reduced potency in comparison.^[1][2][3]

See also

• Benzomorphan

References

1. National Research Council (U.S.). Committee on Problems of Drug Dependence; American Medical Association. Committee on Alcoholism and Drug Dependence; American Medical Association. Council on Mental Health; National Academy of Sciences (U.S.) (1969). Bulletin, problems of drug dependence. National Academies. pp. 5820–5821. NAP:10503. Retrieved 22 April 2012. Cite uses deprecated parameter |coauthors= (help)
2. Smethurst PW, Forrest WH, Hayden J (December 1971). "The respiratory effects of a potent analgesic (GPA 2087) in man". British Journal of Anaesthesia 43 (12): 1129–35. doi:10.1093/bja/43.12.1129. PMID 5156297.
3. National Research Council (U.S.). Committee on Problems of Drug Dependence (1970). Report of the annual scientific meeting. National Research Council. Retrieved 22 April 2012.