FREM2

FRAS1 related extracellular matrix protein 2
Identifiers
Symbols	FREM2 ; DKFZp686J0811; DKFZp781I048; KIAA1074
External IDs	OMIM: 608945 MGI: 2444465 HomoloGene: 18454 GeneCards: FREM2 Gene
Gene ontology Molecular function • calcium ion binding Cellular component • basement membrane • plasma membrane • integral component of membrane • extracellular exosome Biological process • morphogenesis of an epithelium • cell communication • homophilic cell adhesion via plasma membrane adhesion molecules • inner ear development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	341640	242022
Ensembl	ENSG00000150893	ENSMUSG00000037016
UniProt	Q5SZK8	Q6NVD0
RefSeq (mRNA)	NM_207361	NM_172862
RefSeq (protein)	NP_997244	NP_766450
Location (UCSC)	Chr 13: 38.69 – 38.89 Mb	Chr 3: 53.51 – 53.66 Mb
PubMed search

FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.^[1][2]

This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.^[2]

References

1. Smyth I, Du X, Taylor MS, Justice MJ, Beutler B, Jackson IJ (Sep 2004). "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis". Proc Natl Acad Sci U S A 101 (37): 13560–5. doi:10.1073/pnas.0402760101. PMC 518794. PMID 15345741.
2. "Entrez Gene: FREM2 FRAS1 related extracellular matrix protein 2".

Further reading

• Timmer JR, Mak TW, Manova K, Anderson KV, Niswander L; et al. (2005). "Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene.". Proc. Natl. Acad. Sci. U.S.A. 102 (33): 11746–50. doi:10.1073/pnas.0505404102. PMC 1183448. PMID 16087869.

• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dunham A, Matthews LH, Burton J; et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Jadeja S, Smyth I, Pitera JE; et al. (2005). "Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs.". Nat. Genet. 37 (5): 520–5. doi:10.1038/ng1549. PMID 15838507.
• Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Kiyozumi D, Sugimoto N, Sekiguchi K (2006). "Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.". Proc. Natl. Acad. Sci. U.S.A. 103 (32): 11981–6. doi:10.1073/pnas.0601011103. PMC 1567684. PMID 16880404.