Collagen, type IV, alpha 2

Collagen, type IV, alpha 2
PDB rendering based on 1li1.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1LI1​
Identifiers
Symbols	COL4A2 ; ICH; POREN2
External IDs	OMIM: 120090 MGI: 88455 HomoloGene: 1390 GeneCards: COL4A2 Gene
Gene ontology Molecular function • extracellular matrix structural constituent • protein binding Cellular component • extracellular region • collagen type IV trimer • endoplasmic reticulum lumen • extracellular matrix • intracellular membrane-bounded organelle • extracellular exosome Biological process • angiogenesis • transcription, DNA-templated • receptor-mediated endocytosis • axon guidance • negative regulation of angiogenesis • extracellular matrix disassembly • extracellular matrix organization • collagen catabolic process • endodermal cell differentiation • cellular response to transforming growth factor beta stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1284	12827
Ensembl	ENSG00000134871	ENSMUSG00000031503
UniProt	P08572	P08122
RefSeq (mRNA)	NM_001846	NM_009932
RefSeq (protein)	NP_001837	NP_034062
Location (UCSC)	Chr 13: 110.31 – 110.51 Mb	Chr 8: 11.31 – 11.45 Mb
PubMed search

Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene.^[1][2][3]

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.^[3]

References

1. Myers JC, Howard PS, Jelen AM, Dion AS, Macarak EJ (Aug 1987). "Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes". J Biol Chem 262 (19): 9231–8. PMID 2439508.
2. Griffin CA, Emanuel BS, Hansen JR, Cavenee WK, Myers JC (Feb 1987). "Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13". Proc Natl Acad Sci U S A 84 (2): 512–6. doi:10.1073/pnas.84.2.512. PMC 304239. PMID 3025878.
3. "Entrez Gene: COL4A2 collagen, type IV, alpha 2".

Further reading

• Hinek A (1995). "Nature and the multiple functions of the 67-kD elastin-/laminin binding protein.". Cell Adhes. Commun. 2 (3): 185–93. doi:10.3109/15419069409004436. PMID 7827955.
• Ständer M, Naumann U, Wick W, Weller M (1999). "Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth.". Cell Tissue Res. 296 (2): 221–7. doi:10.1007/s004410051283. PMID 10382266.
• Kurpakus Wheater M, Kernacki KA, Hazlett LD (1999). "Corneal cell proteins and ocular surface pathology.". Biotechnic & histochemistry : official publication of the Biological Stain Commission 74 (3): 146–59. doi:10.3109/10520299909047967. PMID 10416788.
• Kalluri R, Sukhatme VP (2000). "Fibrosis and angiogenesis.". Curr. Opin. Nephrol. Hypertens. 9 (4): 413–8. doi:10.1097/00041552-200007000-00013. PMID 10926178.
• Ghebrehiwet B, Peerschke EI, Hong Y; et al. (1992). "Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV.". J. Leukoc. Biol. 51 (6): 546–56. PMID 1377218.
• Gupta S, Batchu RB, Datta K (1992). "Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface.". Eur. J. Cell Biol. 56 (1): 58–67. PMID 1724753.
• Paralkar VM, Nandedkar AK, Pointer RH; et al. (1990). "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen.". J. Biol. Chem. 265 (28): 17281–4. PMID 2211625.
• Hernandez MR, Igoe F, Neufeld AH (1986). "Extracellular matrix of the human optic nerve head.". Am. J. Ophthalmol. 102 (2): 139–48. doi:10.1016/0002-9394(86)90134-0. PMID 2426947.
• Siebold B, Deutzmann R, Kühn K (1988). "The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen.". Eur. J. Biochem. 176 (3): 617–24. doi:10.1111/j.1432-1033.1988.tb14321.x. PMID 2844531.
• Pöschl E, Pollner R, Kühn K (1988). "The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure.". EMBO J. 7 (9): 2687–95. PMC 457057. PMID 2846280.
• Murata K, Motayama T, Kotake C (1986). "Collagen types in various layers of the human aorta and their changes with the atherosclerotic process.". Atherosclerosis 60 (3): 251–62. doi:10.1016/0021-9150(86)90172-3. PMID 3089234.
• Soininen R, Huotari M, Hostikka SL; et al. (1988). "The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region.". J. Biol. Chem. 263 (33): 17217–20. PMID 3182844.
• Hostikka SL, Tryggvason K (1989). "The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain.". J. Biol. Chem. 263 (36): 19488–93. PMID 3198637.
• Brazel D, Pollner R, Oberbäumer I, Kühn K (1988). "Human basement membrane collagen (type IV). The amino acid sequence of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain reveals deletions in the alpha 1(IV) chain.". Eur. J. Biochem. 172 (1): 35–42. doi:10.1111/j.1432-1033.1988.tb13852.x. PMID 3345760.
• Hostikka SL, Kurkinen M, Tryggvason K (1987). "Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region.". FEBS Lett. 216 (2): 281–6. doi:10.1016/0014-5793(87)80706-8. PMID 3582677.
• Killen PD, Francomano CA, Yamada Y; et al. (1988). "Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2).". Hum. Genet. 77 (4): 318–24. doi:10.1007/BF00291418. PMID 3692475.
• Glant TT, Hadházy C, Mikecz K, Sipos A (1985). "Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II.". Histochemistry 82 (2): 149–58. doi:10.1007/bf00708199. PMID 3997552.
• Uscanga L, Kennedy RH, Stocker S; et al. (1984). "Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas.". Digestion 30 (3): 158–64. doi:10.1159/000199100. PMID 6389236.