Flavone 7-O-beta-glucosyltransferase

flavone 7-O-beta-glucosyltransferase
Identifiers
EC number	2.4.1.81
CAS number	37332-50-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a flavone 7-O-beta-glucosyltransferase (EC 2.4.1.81) is an enzyme that catalyzes the chemical reaction

UDP-glucose + 5,7,3',4'-tetrahydroxyflavone $\rightleftharpoons$ UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone

Thus, the two substrates of this enzyme are UDP-glucose and 5,7,3',4'-tetrahydroxyflavone (luteolin), whereas its two products are UDP and 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone (cynaroside).

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase. Other names in common use include UDP-glucose-apigenin beta-glucosyltransferase, UDP-glucose-luteolin beta-D-glucosyltransferase, uridine diphosphoglucose-luteolin glucosyltransferase, uridine diphosphoglucose-apigenin 7-O-glucosyltransferase, and UDP-glucosyltransferase. This enzyme participates in flavonoid biosynthesis.

References

• Sutter A, Ortmann R, Grisebach H (1972). "Purification and properties of an enzyme from cell suspension cultures of parsley catalyzing the transfer of D-glucose from UDP-D-glucose to flavonoids". Biochim. Biophys. Acta 258 (1): 71–87. doi:10.1016/0005-2744(72)90967-9. PMID 5058406.