Glucosylceramide beta-1,4-galactosyltransferase

Glucosylceramide beta-1,4-galactosyltransferase
Identifiers
EC number	2.4.1.274
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Glucosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.274, lactosylceramide synthase, uridine diphosphate-galactose:glucosyl ceramide beta 1-4 galactosyltransferase, UDP-Gal:glucosylceramide beta1->4galactosyltransferase, GalT-2, UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase) is an enzyme with systematic name UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase.^{[1][2][3][4][5]} This enzyme catalyses the following chemical reaction

UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide $\rightleftharpoons$ UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Involved in the synthesis of several different major classes of glycosphingolipids.

References

1. Chatterjee, S. and Castiglione, E. (1987). "UDPgalactose:glucosylceramide β1→4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes". Biochim. Biophys. Acta 923 (1): 136–142. doi:10.1016/0304-4165(87)90136-X. PMID 3099851.
2. Trinchera, M., Fiorilli, A. and Ghidoni, R. (1991). "Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide β1→4galactosyltransferase". Biochemistry 30 (10): 2719–2724. doi:10.1021/bi00224a021. PMID 1900430.
3. Chatterjee, S., Ghosh, N. and Khurana, S. (1992). "Purification of uridine diphosphate-galactose:glucosyl ceramide, β 1-4 galactosyltransferase from human kidney". J. Biol. Chem. 267 (10): 7148–7153. PMID 1551920.
4. Nomura, T., Takizawa, M., Aoki, J., Arai, H., Inoue, K., Wakisaka, E., Yoshizuka, N., Imokawa, G., Dohmae, N., Takio, K., Hattori, M. and Matsuo, N. (1998). "Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide β-1,4-galactosyltransferase from rat brain". J. Biol. Chem. 273 (22): 13570–13577. doi:10.1074/jbc.273.22.13570. PMID 9593693.
5. Takizawa, M., Nomura, T., Wakisaka, E., Yoshizuka, N., Aoki, J., Arai, H., Inoue, K., Hattori, M. and Matsuo, N. (1999). "cDNA cloning and expression of human lactosylceramide synthase". Biochim. Biophys. Acta 1438 (2): 301–304. doi:10.1016/S1388-1981(99)00051-7. PMID 10320813.

External links

• Glucosylceramide beta-1,4-galactosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)