Glycosyltransferase DesVII

Glycosyltransferase DesVII
Identifiers
EC number	2.4.1.277
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Glycosyltransferase DesVII (EC 2.4.1.277, DesVII) is an enzyme with systematic name dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose:10-deoxymethynolide 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase.^[1][2][3] This enzyme catalyses the following chemical reaction

dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide $\rightleftharpoons$ dTDP + 10-deoxymethymycin

DesVII is the glycosyltransferase responsible for the attachment of TDP-D-desosamine to macrolactones of varied ring sizes.

References

1. Borisova, S.A. and Liu, H.W. (2010). "Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway". Biochemistry 49 (37): 8071–8084. doi:10.1021/bi1007657. PMC 2939310. PMID 20695498.
2. Borisova, S.A., Kim, H.J., Pu, X. and Liu, H.W. (2008). "Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications". Chembiochem. 9 (10): 1554–1558. doi:10.1002/cbic.200800155. PMID 18548476.
3. Hong, J.S., Park, S.J., Parajuli, N., Park, S.R., Koh, H.S., Jung, W.S., Choi, C.Y. and Yoon, Y.J. (2007). "Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation". Gene 386 (1–2): 123–130. doi:10.1016/j.gene.2006.08.021. PMID 17049185.

External links

• Glycosyltransferase DesVII at the US National Library of Medicine Medical Subject Headings (MeSH)