Interleukin 28 receptor, alpha subunit

Interferon, lambda receptor 1
Rendering based on PDB 3OG4​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3OG4​, 3OG6​
Identifiers
Symbols	IFNLR1 ; CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2
External IDs	OMIM: 607404 MGI: 2429859 HomoloGene: 52086 GeneCards: IFNLR1 Gene
Gene ontology Molecular function • cytokine receptor activity • protein binding Cellular component • plasma membrane • integral component of membrane • interleukin-28 receptor complex Biological process • mucosal immune response • negative regulation of cell proliferation • cytokine-mediated signaling pathway • response to type III interferon • regulation of defense response to virus by host • defense response to virus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	163702	242700
Ensembl	ENSG00000185436	ENSMUSG00000062157
UniProt	Q8IU57	Q8CGK5
RefSeq (mRNA)	NM_170743	NM_174851
RefSeq (protein)	NP_734464	NP_777276
Location (UCSC)	Chr 1: 24.15 – 24.19 Mb	Chr 4: 135.69 – 135.71 Mb
PubMed search

Interleukin 28 receptor, alpha subunit is a subunit for the interleukin-28 receptor. IL28RA is its human gene.

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukin 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.^[1]

References

1. "Entrez Gene: IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor)".