Josamycin
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Systematic (IUPAC) name | |
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(2S,3S,4R,6S) -6- {[(2R,3S,4R,5R,6S) -6- {[(4R,5S,6S,7R,9R,10R,11E,13E,16R) -4- (acetyloxy)-10-hydroxy-5-methoxy-9, 16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11, 13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy}-4-hydroxy-2, 4-dimethyloxan-3-yl 3-methylbutanoate | |
Clinical data | |
AHFS/Drugs.com | International Drug Names |
Identifiers | |
CAS Number |
16846-24-5 ![]() |
ATC code | J01FA07 (WHO) |
PubChem | CID 5284579 |
DrugBank |
DB01321 ![]() |
ChemSpider |
4447629 ![]() |
UNII |
HV13HFS217 ![]() |
KEGG |
D01235 ![]() |
ChEBI |
CHEBI:31739 ![]() |
ChEMBL |
CHEMBL224436 ![]() |
PDB ligand ID | JOS (PDBe, RCSB PDB) |
Chemical data | |
Formula | C42H69NO15 |
Molar mass | 827.995 g/mol |
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Josamycin is a macrolide antibiotic. It is synthesized from strains of Streptomyces narbonensis var. josamyceticus var. nova
Currently sold in various countries.
Brand examples are:
Europe: Josalid, Josacine, Iosalide, Josamina. Russia: Wilprafen (Вильпрафен). Japan: Josamy.
Adverse effects
There has been a case report of oedema of the feet.[1]
References
- ↑ Bosch, X.; Pedrol, E.; Casado, X.; Urbano-Marquez, A. (1993). "Josamycin-induced pedal oedema" (pdf). British Medical Journal (Clinical research ed.) 307 (6895): 26. doi:10.1136/bmj.307.6895.26-a. PMC 1678472. PMID 8343666.
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