Lactosylceramide beta-1,3-galactosyltransferase

lactosylceramide beta-1,3-galactosyltransferase
Identifiers
EC number	2.4.1.179
CAS number	106769-64-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a lactosylceramide beta-1,3-galactosyltransferase (EC 2.4.1.179) is an enzyme that catalyzes the chemical reaction

UDP-galactose + D-galactosyl-1,4-beta-D-glucosyl-R $\rightleftharpoons$ UDP + D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R

Thus, the two substrates of this enzyme are UDP-galactose and D-galactosyl-1,4-beta-D-glucosyl-R, whereas its two products are UDP and D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase. Other names in common use include uridine diphosphogalactose-lactosylceramide, and beta1->3-galactosyltransferase.

References

• Bailly P, Piller F, Cartron JP (1988). "Characterization and specific assay for a galactoside beta-3-galactosyltransferase of human kidney". Eur. J. Biochem. 173 (2): 417–22. doi:10.1111/j.1432-1033.1988.tb14015.x. PMID 3129295.