| Title | Original running | Production | Notes |
| The Wuzzles | 1985 | Produced by Disney Television Animation | |
| Disney's Adventures of the Gummi Bears | 1985–1991 | Produced by Disney Television Animation | |
| DuckTales | 1987–1990 | Produced by Disney Television Animation | Based on comic stories by Carl Barks. |
| The New Adventures of Winnie the Pooh | 1988–1991 | Produced by Disney Television Animation | First animated series featuring Winnie the Pooh. |
| Chip 'n Dale Rescue Rangers | 1989–1990 | Produced by Disney Television Animation | Based on classic theatrical shorts. |
| TaleSpin | 1990–1991 | Produced by Disney Television Animation | Based on characters from The Jungle Book. |
| Darkwing Duck | 1991–1992 | Produced by Disney Television Animation | First spin-off of DuckTales. |
| Goof Troop | 1992–1993 | Produced by Disney Television Animation | Based on classic theatrical shorts. |
| The Little Mermaid | 1992–1994 | Produced by Disney Television Animation | First series based on the Disney animation canon. |
| Raw Toonage | 1992 | Produced by Disney Television Animation | |
| Bonkers | 1993–1994 | Produced by Disney Television Animation | First spin-off of Raw Toonage. |
| Marsupilami | 1993 | Produced by Disney Television Animation, in association with Marsu Productions. Second spin-off of Raw Toonage. |
| Aladdin | 1994–1995 | Produced by Disney Television Animation | Second series based on the Disney animation canon. |
| Gargoyles | 1994–1997 | Produced by Disney Television Animation | |
| The Shnookums and Meat Funny Cartoon Show | 1995 | Produced by Disney Television Animation | Spin-off of Marsupilami. |
| The Lion King's Timon & Pumbaa | 1995–1999 | Produced by Disney Television Animation | Third series based on the Disney animation canon. |
| Quack Pack | 1996 | Produced by Disney Television Animation | Second spin-off of DuckTales. |
| Disney's Mighty Ducks | 1996–1997 | Produced by Disney Television Animation | Loosely spun off from the Mighty Ducks film series. |
| Jungle Cubs | 1996–1998 | Produced by Disney Television Animation | Fourth series based on the Disney animation canon. |
| Disney's Doug | 1996–2000 | Produced by Jumbo Pictures | Co-produced by Disney Television Animation Seasons 4–7 only, originally produced by Nickelodeon seasons 1–3. |
| 101 Dalmatians | 1997–1998 | Produced by Disney Television Animation | Fifth series based on the Disney animated canon. |
| Nightmare Ned | 1997 | Produced by Disney Television Animation | |
| Recess | 1997–2003 | Produced by Disney Television Animation | |
| Pepper Ann | 1997–2002 | Produced by Disney Television Animation | |
| Hercules | 1998–1999 | Produced by Disney Television Animation | Sixth series based on the Disney animation canon. |
| PB&J Otter | 1998–2000 | Produced by Jumbo Pictures. | Playhouse Disney's 1st animated original series |
| The Weekenders | 1999–2004 | Produced by Disney Television Animation | |
| Mickey Mouse Works | 1996–1999 | Produced by Disney Television Animation |
Created in the spirit of the classic theatrical shorts. |
| Teacher's Pet | 2000–2002 | Produced by Disney Television Animation | |
| Buzz Lightyear of Star Command | 2000–2002 | Produced by Disney Television Animation and Pixar Animation Studios. | Based on the Toy Story franchise. |
| Disney's House of Mouse | 2000–2003 | Produced by Disney Television Animation | Based on the classic theatrical shorts. |
| Lloyd in Space | 2001–2004 | Produced by Disney Television Animation. | |
| The Legend of Tarzan | 2001–2003 | Produced by Disney Television Animation. | Seventh series based on the Disney animation canon. |
| The Proud Family | 2001–2005 | Produced by Jambalaya Studios. | Disney Channel's 1st animated original series. |
| Teamo Supremo | 2002–2004 | Produced by Disney Television Animation. | |
| Stanley | 2001–2004 | Produced by Cartoon Pizza. | Playhouse Disney's 2nd animated original series. |
| Kim Possible | 2002–2007 | Produced by Disney Television Animation. | Disney Channel's 2nd animated original series. |
| Pucca | 2006–2008 | Produced by Studio B Productions. | Disney Channel's 3rd animated original series. |
| Fillmore! | 2002–2004 | Produced by Disney Television Animation. | Last series in the original Disney television animation canon. |
| Lilo & Stitch: The Series | 2003–2006 | Produced by Disney Television Animation. | Disney Channel's 3rd animated original series, eighth series based on the Disney animation canon. |
| JoJo's Circus | 2003–2007 | Produced by Cartoon Pizza. | Playhouse Disney's 3rd animated original series and first series to use stop-motion animation. |
| Dave the Barbarian | 2004–2005 | Produced by Disney Television Animation. | Disney Channel's 4th animated original series. |
| Brandy & Mr. Whiskers | 2004–2006 | Produced by Disney Television Animation. | Disney Channel's 5th animated original series. |
| Higglytown Heroes | 2004–2008 | Produced by Wild Brain. | Playhouse Disney's 4th animated original series. |
| Super Robot Monkey Team Hyperforce Go! | 2004–2006 | Produced by Jetix Animation Concepts. | Jetix's 1st original series. |
| W.I.T.C.H. | 2004–2006 | Produced by Jetix EUROPE. | Jetix's 2nd original series. |
| American Dragon: Jake Long | 2005–2007 | Produced by Disney Television Animation. | Disney Channel's 6th animated original series. |
| The Buzz on Maggie | 2005–2006 | Produced by Disney Television Animation. | Disney Channel's 7th animated original series. |
| Little Einsteins | 2005–2009 | Produced by Curious Pictures. | Playhouse Disney's 5th animated original series. |
| A.T.O.M. | 2005–2006 | Produced by Jetix EUROPE. | Jetix's 3rd original series. |
| Get Ed | 2005–2006 | Produced by Jetix Animation Concepts. | Jetix's 4th original series. |
| Yin Yang Yo! | 2006–2009 | Produced by Jetix Animation Concepts. | Jetix's 5th original series. |
| Ōban Star-Racers | 2006 | Produced by Jetix EUROPE. | Jetix's 6th original series. |
| The Emperor's New School | 2006–2009 | Produced by Disney Television Animation. | Disney Channel's 8th animated original series. Ninth series based on the Disney animation canon. |
| The Replacements | 2006–2009 | Produced by Disney Television Animation. | Disney Channel's 9th animated original series. |
| Shorty McShorts' Shorts | 2006–2007 | Produced by Disney Television Animation. | |
| Bunnytown | 2007–2009 | Produced by Baker Coogan Productions and Spiffy Pictures. | Playhouse Disney's 8th animated original series. live action/animation hybrid. |
| My Friends Tigger & Pooh | 2007–2010 | Produced by Disney Television Animation. | Playhouse Disney's 9th animated original series. Second animated series featuring Winnie the Pooh. |
| Upin & Ipin | 2007–present | Produced by Les' Copaque Production Sdn. Bhd., animation production Walt Disney Television Animation (Malaysia) and ITV Studios, in association with TV9 (Malaysia) and Disney Channel Asia. | Disney Channel's 4th animated original series. First animated series featuring Upin and Ipin. |
| Monster Buster Club | 2008–2010 | Produced by Jetix EUROPE. | Jetix's 7th original series. |
| Kid vs. Kat | 2009–2011 | Produced by Studio B Productions, | in association with YTV. |
| Stitch! | 2008–2011 | Produced by Walt Disney Television Animation Japan, Inc., Madhouse and Shin-Ei Animation, in association with Disney Channel Asia. | Disney Channel's 3rd animated original series is Disney's 2nd anime series, seventh series based on the Disney animation canon of Lilo & Stitch: The Series. |
| Handy Manny | 2006–2015 | Produced by Nelvana. | Playhouse Disney's 7th animated original series. |
| Special Agent Oso | 2009–2015 | Produced by Disney Television Animation. | Playhouse Disney's 10th animated original series. |
| Jungle Junction | 2009–2012 | Produced by Spider Eye Productions. | Playhouse Disney's 11th animated original series. |
| Kick Buttowski: Suburban Daredevil | 2010–2013 | Produced by Disney Television Animation. | Disney XD's 1st animated original series. |
| Tron: Uprising | 2012–2013 | Produced by Disney Television Animation. Co-produced by Sean Bailey Productions. | Disney XD's 2nd original series, based on the Tron franchise. |
| Fish Hooks | 2010–2014 | Produced by Disney Television Animation. | Disney Channel's 11th animated original series. |
| Phineas and Ferb | 2007–2015 | Produced by Disney Television Animation. | Disney Channel's 10th animated original series. |
| Cars Toons: Mater's Tall Tales | 2008–2013 | Produced by Pixar Animation Studios. | |
| Jimmy Two-Shoes | 2009–2012 | Produced by Studio B Productions, | in association with YTV. |
| Take Two with Phineas and Ferb | 2010–2011 | Produced by Disney Television Animation. | Co-produced by Hieroglyphic Productions. live action/animation hybrid |
| Special Agent Oso: Three Healthy Steps | 2011–2013 | Produced by Disney Television Animation. | |
| A Poem Is... | 2011–2013 | Produced by Disney Television Animation. | |
| Motorcity | 2012–2013 | Produced by Disney Television Animation. Co-produced with Titmouse, Inc.. | Disney XD's 2nd animated original series. |
| Ongoing |
| Mickey Mouse Clubhouse | 2006–present | Produced by Disney Television Animation. | Playhouse Disney's 6th animated original series. |
| Jake and the Never Land Pirates | 2011–present | Produced by Disney Television Animation. | Disney Junior's 1st original series. |
| Mickey Mousekersize | 2011–present | Produced by Disney Television Animation. | |
| Minnie's Bow-Toons | 2011–present | Produced by Disney Television Animation. | |
| Doc McStuffins | 2012–present | Produced by Brown Bag Films; | Disney Junior's 2nd original series. |
| Ultimate Spider-Man | 2012–present | Produced by Marvel Animation. | |
| Gravity Falls | 2012–2016 | Produced by Disney Television Animation. | Disney Channel's 12th animated original series. |
| Randy Cunningham: 9th Grade Ninja | 2012–2014 | Produced by Disney Television Animation; Co-produced with Titmouse, Inc., Boulder Media Limited and Rough Draft Studios Korea Co., Ltd. | Disney XD's 4th animated original series. |
|
|
| Mickey Mouse | 2013–present | Produced by Disney Television Animation. | Created in the spirit of the classic theatrical shorts. |
| Henry Hugglemonster | 2013–? | Produced by Brown Bag Films. | Disney Junior's 3rd original series. |
| Sheriff Callie's Wild West | 2014–present | Produced by Wild Brain. | Disney Junior's 4th original series. |
| Sofia the First | 2012–present | Produced by Disney Television Animation. | Disney Junior's 5th original series. |
| The 7D | 2014-? | Produced by Disney Television Animation. | Disney Junior's 6th original series. |
| Wander Over Yonder | 2013–present | Produced by Disney Television Animation. | Disney Channel's 13th animated original series. |
| Hulk and the Agents of S.M.A.S.H. | 2013–present | Produced by Marvel Animation. | |
| Pac-Man: The Adventure Begins | 2013–2014 | Produced by Namco. | |
| Star Wars Rebels | 2014–present | Produced by Lucasfilm. | |
| Star vs. the Forces of Evil | 2015–present | Produced by Disney Television Animation. | |