List of adaptins

Main article: Clathrin adaptor proteins

Adaptins are proteins that mediate the formation of vesicles by clathrin-coated pits, through interaction with membrane-bound receptors. There are several types of adaptin, each related to a different group of such receptors.

Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin.

Adaptins cluster to form the AP2 complex.

The Adaptin complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma):

complex 1
- AP1B1
- AP1G1
- AP1G2
- AP1M1
- AP1M2
- AP1S1
- AP1S2
- AP1S3
complex 2
- AP2A1
- AP2A2
- AP2B1
- AP2M1
- AP2S1
complex 3
- AP3B1
- AP3B2
- AP3M1
- AP3M2
- AP3S1
- AP3S2
complex 4
- AP4B1
- AP4E1
- AP4M1
- AP4S1
complex 5
- complex 5 has been discovered at the university of Alberta, Canada, little is yet known of the internal constructs that make up the complex.

References

Alberts, Johnson, Lewis, Raff, Roberts, Walter: Molecular Biology of the Cell, 4th edition (2002), Garland Science.

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