STK3

Serine/threonine kinase 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4HKD​, 4L0N​, 4LG4​, 4LGD​, 4OH9​
Identifiers
Symbols	STK3 ; KRS1; MST2
External IDs	OMIM: 605030 MGI: 1928487 HomoloGene: 48420 IUPHAR: 2219 ChEMBL: 4708 GeneCards: STK3 Gene
EC number	2.7.11.1
Gene ontology Molecular function • magnesium ion binding • protein kinase activity • protein serine/threonine kinase activity • MAP kinase kinase kinase activity • protein binding • ATP binding • protein serine/threonine kinase activator activity • protein dimerization activity Cellular component • nucleus • cytoplasm • cytosol • protein complex Biological process • MAPK cascade • activation of MAPKK activity • neural tube formation • endocardium development • protein phosphorylation • apoptotic process • signal transduction • regulation of mitotic cell cycle • central nervous system development • negative regulation of cell proliferation • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • positive regulation of protein binding • hippo signaling • intracellular signal transduction • regulation of apoptotic process • positive regulation of apoptotic process • positive regulation of fat cell differentiation • positive regulation of JNK cascade • negative regulation of organ growth • protein stabilization • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of protein kinase B signaling • primitive hemopoiesis • cell differentiation involved in embryonic placenta development • regulation of cell differentiation involved in embryonic placenta development • positive regulation of protein serine/threonine kinase activity • negative regulation of canonical Wnt signaling pathway • hepatocyte apoptotic process • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6788	56274
Ensembl	ENSG00000104375	ENSMUSG00000022329
UniProt	Q13188	Q9JI10
RefSeq (mRNA)	NM_001256312	NM_019635
RefSeq (protein)	NP_001243241	NP_062609
Location (UCSC)	Chr 8: 98.4 – 98.94 Mb	Chr 15: 34.88 – 35.16 Mb
PubMed search

Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.^[1][2]

Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was first identified as a kinase that resembles budding yeast Ste20 (Creasy and Chernoff, 1996) and later as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996; Lee et al., 2001).[supplied by OMIM]^[2]

References

1. Taylor LK, Wang HC, Erikson RL (Nov 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc Natl Acad Sci U S A 93 (19): 10099–104. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.
2. "Entrez Gene: STK3 serine/threonine kinase 3 (STE20 homolog, yeast)".

Further reading

• Creasy CL, Chernoff J (1995). "Cloning and characterization of a human protein kinase with homology to Ste20". J. Biol. Chem. 270 (37): 21695–700. doi:10.1074/jbc.270.37.21695. PMID 7665586.
• Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
• Creasy CL, Chernoff J (1996). "Cloning and characterization of a member of the MST subfamily of Ste20-like kinases". Gene 167 (1–2): 303–6. doi:10.1016/0378-1119(95)00653-2. PMID 8566796.
• Bren A, Welch M, Blat Y, Eisenbach M (1996). "Signal termination in bacterial chemotaxis: CheZ mediates dephosphorylation of free rather than switch-bound CheY". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10090–3. doi:10.1073/pnas.93.19.10090. PMC 38341. PMID 8816756.
• Wang HC, Fecteau KA (2000). "Detection of a novel quiescence-dependent protein kinase". J. Biol. Chem. 275 (33): 25850–7. doi:10.1074/jbc.M000818200. PMID 10840030.
• Lee KK, Ohyama T, Yajima N, et al. (2001). "MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation". J. Biol. Chem. 276 (22): 19276–85. doi:10.1074/jbc.M005109200. PMID 11278283.
• De Souza PM, Kankaanranta H, Michael A, et al. (2002). "Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis". Blood 99 (9): 3432–8. doi:10.1182/blood.V99.9.3432. PMID 11964314.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deng Y, Pang A, Wang JH (2003). "Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis". J. Biol. Chem. 278 (14): 11760–7. doi:10.1074/jbc.M211085200. PMID 12554736.
• Rabizadeh S, Xavier RJ, Ishiguro K, et al. (2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi:10.1074/jbc.M401699200. PMID 15075335.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• O'Neill E, Rushworth L, Baccarini M, Kolch W (2005). "Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1". Science 306 (5705): 2267–70. doi:10.1126/science.1103233. PMID 15618521.
• Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006.
• Oh HJ, Lee KK, Song SJ, et al. (2006). "Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis". Cancer Res. 66 (5): 2562–9. doi:10.1158/0008-5472.CAN-05-2951. PMID 16510573.
• Callus BA, Verhagen AM, Vaux DL (2006). "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation". FEBS J. 273 (18): 4264–76. doi:10.1111/j.1742-4658.2006.05427.x. PMID 16930133.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Seidel C, Schagdarsurengin U, Blümke K, et al. (2007). "Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma". Mol. Carcinog. 46 (10): 865–71. doi:10.1002/mc.20317. PMID 17538946.
• Matallanas D, Romano D, Yee K, et al. (2007). "RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein". Mol. Cell 27 (6): 962–75. doi:10.1016/j.molcel.2007.08.008. PMC 2821687. PMID 17889669.