Meprin A

Meprin A
Identifiers
EC number 3.4.24.18
CAS number 148938-24-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Meprin A (EC 3.4.24.18, endopeptidase-2, meprin-a, meprin, N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PABA-peptide hydrolase, PPH) is an enzyme that cleaves protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.[1]

Meprin A is a dimer composed of the products transcribed from the following two genes:

meprin A, alpha
Identifiers
Symbol MEP1A
Entrez 4224
HUGO 7015
OMIM 600388
RefSeq NM_005588
UniProt Q16819
Other data
EC number 3.4.24.18
Locus Chr. 6 p12-p11
meprin A, beta
Identifiers
Symbol MEP1B
Entrez 4225
HUGO 7020
OMIM 600389
RefSeq NM_005925
UniProt Q16820
Other data
EC number 3.4.24.18
Locus Chr. 18 q12.2-12.3

References

  1. Sterchi EE, Stöcker W, Bond JS (October 2008). "Meprins, membrane-bound and secreted astacin metalloproteinases". Mol. Aspects Med. 29 (5): 309–28. doi:10.1016/j.mam.2008.08.002. PMC 2650038. PMID 18783725.
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