mir-145

MicroRNA 145
Identifiers
Symbols MIR145 ; MIRN145; miR-145; miRNA145
External IDs OMIM: 611795 GeneCards: MIR145 Gene
Orthologs
Species Human Mouse
Entrez 406937 n/a
Ensembl ENSG00000269936 n/a
UniProt n/a n/a
RefSeq (mRNA) NR_029686 n/a
RefSeq (protein) n/a n/a
Location (UCSC) Chr 5:
149.43 – 149.43 Mb
n/a
PubMed search n/a
mir-145
Conserved secondary structure of mir-145
Identifiers
Symbol mir-145
Rfam RF00675
miRBase family MIPF0000079
Other data
RNA type microRNA
Domain(s) Eukaryota;

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.[1]

Targets

MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin.[2] Larsson et al.[3] showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al.[4]

Role in cancer

miR-145 is hypothesised to be a tumor suppressor.[5] miR-145 has been shown to be down-regulated in breast cancer.[2] miR-145 is also involved in colon cancer [4][6] and acute myeloid leukemia.[7]

References

  1. "Entrez Gene: MicroRNA 145". Retrieved 2015-01-26.
  2. 1 2 Götte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M, Ibrahim SA, Peddibhotla S, Teng YH, Low JY, Ebnet K, Kiesel L, Yip GW (Dec 2010). "miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene 29 (50): 6569–80. doi:10.1038/onc.2010.386. PMID 20818426.
  3. Larsson E, Fredlund Fuchs P, Heldin J, Barkefors I, Bondjers C, Genové G, Arrondel C, Gerwins P, Kurschat C, Schermer B, Benzing T, Harvey SJ, Kreuger J, Lindahl P (2009). "Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1". Genome Medicine 1 (11): 108. doi:10.1186/gm108. PMC 2808743. PMID 19917099.
  4. 1 2 Zhang J, Guo H, Zhang H, Wang H, Qian G, Fan X, Hoffman AR, Hu JF, Ge S (Jan 2011). "Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene". Cancer 117 (1): 86–95. doi:10.1002/cncr.25522. PMC 2995010. PMID 20737575.
  5. Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY (Mar 2009). "p53 represses c-Myc through induction of the tumor suppressor miR-145". Proceedings of the National Academy of Sciences of the United States of America 106 (9): 3207–12. doi:10.1073/pnas.0808042106. PMC 2651330. PMID 19202062.
  6. Slaby O, Svoboda M, Fabian P, Smerdova T, Knoflickova D, Bednarikova M, Nenutil R, Vyzula R (2007). "Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer". Oncology 72 (5-6): 397–402. doi:10.1159/000113489. PMID 18196926.
  7. Starczynowski DT, Morin R, McPherson A, Lam J, Chari R, Wegrzyn J, Kuchenbauer F, Hirst M, Tohyama K, Humphries RK, Lam WL, Marra M, Karsan A (Jan 2011). "Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations". Blood 117 (2): 595–607. doi:10.1182/blood-2010-03-277012. PMID 20962326.

Further reading

External links

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