mir-BHRF1-3 microRNA precursor family

mir-BHRF1-3 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-BHRF1-3
Identifiers
Symbol mir-BHRF1-3
Rfam RF00367
Other data
RNA type Gene; miRNA
Domain(s) Viruses
GO 0035195 0035068
SO 0001244

The mir-BHRF1-3 microRNA precursor found in Human herpesvirus 4 (Epstein-Barr virus). In Epstein-Barr virus, mir-BHRF1-3 is found in the 3' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 5' arm of the hairpin.[1] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-1 and Mir-BHRF1-2.[1]

BHRF-1-3 miRNA is though to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein-Barr virus genome.[2] BHRF-3 has been shown to be expressed in latency-III infected lymphoblasts.[3]

References

  1. 1 2 Pfeffer, S; Zavolan M; Grasser FA; Chien M; Russo JJ; Ju J; John B; Enright AJ; Marks D; Sander C; Tuschl T (2004). "Identification of Virus-Encoded MicroRNAs". Science 304 (5671): 734736. doi:10.1126/science.1096781. PMID 15118162.
  2. Feederle, R; Haar, J; Bernhardt, K; Linnstaedt, SD; Bannert, H; Lips, H; Cullen, BR; Delecluse, HJ (Jul 13, 2011). "The members of a viral miRNA cluster co-operate to transform B lymphocytes.". Journal of Virology 85 (19): 9801–10. doi:10.1128/JVI.05100-11. PMC 3196389. PMID 21752900.
  3. Xing, L; Kieff, E (September 2007). "Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication.". Journal of Virology 81 (18): 9967–75. doi:10.1128/JVI.02244-06. PMC 2045418. PMID 17626073.

External links

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