N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase
Identifiers
EC number	2.4.1.150
CAS number	85638-40-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (EC 2.4.1.150) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R $\rightleftharpoons$ UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D- glucosaminyl-R

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R, whereas its 3 products are UDP, N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-, and glucosaminyl-R.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosam inide beta-1,6-N-acetyl-D-glucosaminyltransferase. Other names in common use include N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide, beta1->6-acetylglucosaminyltransferase, Galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase, and UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase. This enzyme participates in glycosphingolipid biosynthesis - neo-lactoseries and glycan structures - biosynthesis 2.

References

• van den Eijnden DH, Winterwerp H, Smeeman P, Schiphorst WE (1983). "Novikoff ascites tumor cells contain N-acetyllactosaminide beta 1 leads to 3 and beta 1 leads to 6 N-acetylglucosaminyltransferase activity". J. Biol. Chem. 258 (6): 3435–7. PMID 6219989.