N-acetylneuraminylgalactosylglucosylceramide b-1,4-N-acetylgalactosaminyltransferase

N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase
Identifiers
EC number	2.4.1.165
CAS number	109136-50-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.165, uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase, UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-N-acetylgalactosaminyltransferase.^[1][2][3] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-galactosamine + N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide $\rightleftharpoons$ UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

This enzyme requires Mn²⁺.

References

1. Chien, J.-L., Williams, T. and Basu, S. (1973). "Biosynthesis of a globoside-type glycosphingolipid by a β-N-acetylgalactosaminyltransferase from embryonic chicken brain". J. Biol. Chem. 248 (5): 1778–1785. PMID 4632917.
2. Piller, F., Blanchard, D., Huet, M. and Cartron, J.-P. (1986). "Identification of a α-NeuAc-(2-3)-β-D-galactopyranosyl N-acetyl-β-D-galactosaminyltransferase in human kidney". Carbohydr. Res. 149: 171–184. doi:10.1016/S0008-6215(00)90376-8. PMID 2425965.
3. Takeya, A., Hosomi, O. and Kogure, T. (1987). "Identification and characterization of UDP-GalNAc: NeuAc α2-3Gal β1-4Glc(NAc) β1-4(GalNAc to Gal)N-acetylgalactosaminyltransferase in human blood plasma". J. Biochem. (Tokyo) 101 (1): 251–259. PMID 3106337.

External links

• N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)