Noroxymorphone

Noroxymorphone

Systematic (IUPAC) name
7,8-Dihydro-14-hydroxynormorphinone
Clinical data
Routes of administration	intravenous, intramusucular, subcutaneous, oral, rectal, intranasal
Legal status
Legal status	US: Schedule II
Identifiers
CAS Number	33522-95-1
PubChem	CID 5497189
DrugBank	DBMET00424
ChemSpider	4593755
UNII	9NZ7111A9O
Chemical data
Formula	C16H17NO4
Molar mass	287.32 g·mol^−1
SMILES Oc1ccc2C[C@H]3NCC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
InChI InChI=1S/C16H17NO4/c18-9-2-1-8-7-11-16(20)4-3-10(19)14-15(16,5-6-17-11)12(8)13(9)21-14/h1-2,11,14,17-18,20H,3-7H2/t11-,14+,15+,16-/m1/s1 Key:HLMSIZPQBSYUNL-IPOQPSJVSA-N

Noroxymorphone is an opioid^[1] which is both a metabolite of oxymorphone and is manufactured specifically as an intermediate in the production of narcotic antagonists such as naltrexone and others.

In the United States, noroxymorphone is controlled as a Schedule II Narcotic controlled substance with an ACSCN of 9637 and in 2014 the DEA set annual aggregate manufacturing quotas of 17 500 kilogrammes for conversion and 1262.5 kg for sale.^[2] In other countries, it may be similarly controlled, controlled at a lower level, or regulated in another way.

See also

• Oxymorphone hydrazone
• Oxymorphol - a metabolite of oxymorphone and an intermediate in the creation of hydromorphone
• Hydromorphone
• Oxycodone
• Drug addiction

References

1. Lemberg, Kim K.; Siiskonen, Antti O.; Kontinen, Vesa K.; Yli-Kauhaluoma, Jari T.; Kalso, Eija A. (February 2008). "Pharmacological Characterization of Noroxymorphone as a New Opioid for Spinal Analgesia". Anesthesia & Analgesia: 106 (2): 463–470. doi:10.1213/ane.0b013e3181605a15. PMID 18227301.
2. Drug Enforcement Administration (August 25, 2014). "Final Adjusted Aggregate Production Quotas for Schedule I and II Controlled Substances and Assessment of Annual Needs for the List I Chemicals Ephedrine, Pseudoephedrine, and Phenylpropanolamine for 2014". Federal Register. Vol. 79 no. 164. pp. 50700–50704.