Small nuclear ribonucleoprotein polypeptide F

Small nuclear ribonucleoprotein polypeptide F
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3CW1​, 3PGW​, 3S6N​, 4F7U​, 4PJO​, 4V98​, 4WZJ​
Identifiers
Symbols	SNRPF ; SMF; Sm-F; snRNP-F
External IDs	OMIM: 603541 MGI: 1917128 HomoloGene: 130366 GeneCards: SNRPF Gene
Gene ontology Molecular function • RNA binding • protein binding Cellular component • nucleoplasm • spliceosomal complex • U7 snRNP • U1 snRNP • U4 snRNP • U12-type spliceosomal complex • small nucleolar ribonucleoprotein complex • cytosol • small nuclear ribonucleoprotein complex • methylosome • pICln-Sm protein complex • SMN-Sm protein complex • catalytic step 2 spliceosome Biological process • spliceosomal snRNP assembly • mRNA splicing, via spliceosome • transcription from RNA polymerase II promoter • termination of RNA polymerase II transcription • histone mRNA metabolic process • RNA splicing • gene expression • mRNA 3'-end processing • ncRNA metabolic process • activation of mitophagy in response to mitochondrial depolarization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6636	69878
Ensembl	ENSG00000139343	ENSMUSG00000020018
UniProt	P62306	P62307
RefSeq (mRNA)	NM_003095	NM_027246
RefSeq (protein)	NP_003086	NP_081522
Location (UCSC)	Chr 12: 95.86 – 95.9 Mb	Chr 10: 93.58 – 93.59 Mb
PubMed search

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.^[1][2]

Interactions

Small nuclear ribonucleoprotein polypeptide F has been shown to interact with DDX20,^[3] Small nuclear ribonucleoprotein D2^[4] and Small nuclear ribonucleoprotein polypeptide E.^[4]

References

1. Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Luhrmann R (June 1995). "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". EMBO J 14 (9): 2076–88. PMC 398308. PMID 7744013.
2. "Entrez Gene: SNRPF small nuclear ribonucleoprotein polypeptide F".
3. Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. (UNITED STATES) 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333.
4. Fury, M G; Zhang W; Christodoulopoulos I; Zieve G W (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. (UNITED STATES) 237 (1): 63–9. doi:10.1006/excr.1997.3750. ISSN 0014-4827. PMID 9417867.

Further reading

• Sauterer RA, Goyal A, Zieve GW (1990). "Cytoplasmic assembly of small nuclear ribonucleoprotein particles from 6 S and 20 S RNA-free intermediates in L929 mouse fibroblasts". J. Biol. Chem. 265 (2): 1048–58. PMID 1688550.
• Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles". J. Biol. Chem. 264 (10): 5776–83. PMID 2522439.
• Woppmann A, Rinke J, Lührmann R (1989). "Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ". Nucleic Acids Res. 16 (23): 10985–1004. doi:10.1093/nar/16.23.10985. PMC 338992. PMID 2974540.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Plessel G, Lührmann R, Kastner B (1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core". J. Mol. Biol. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
• Kambach C, Walke S, Young R, et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403.
• Bühler D, Raker V, Lührmann R, Fischer U (2000). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy". Hum. Mol. Genet. 8 (13): 2351–7. doi:10.1093/hmg/8.13.2351. PMID 10556282.
• Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
• Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
• Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein–Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
• Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
• Friesen WJ, Wyce A, Paushkin S, et al. (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.