(3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring))-phosphatase

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(3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring))-phosphatase (EC 3.1.3.52, branched-chain oxo-acid dehydrogenase phosphatase, branched-chain 2-keto acid dehydrogenase phosphatase, branched-chain alpha-keto acid dehydrogenase phosphatase, BCKDH, [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase, [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphate phosphohydrolase) is an enzyme with systematic name (3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring))-phosphate phosphohydrolase.^[1]^[2] This enzyme catalyses the following chemical reaction

[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] phosphate + H₂O

\rightleftharpoons

[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] + phosphate

This mitochondrial enzyme is associated with the 3-methyl-2-oxobutanoate dehydrogenase complex.

References

↑ Fatania, H.R., Patston, P.A. and Randle, P.J. (1983). "Dephosphorylation and reactivation of phosphorylated purified ox-kidney branched-chain dehydrogenase complex by co-purified phosphatase". FEBS Lett. 158: 234–238. doi:10.1016/0014-5793(83)80585-7. PMID 6307746.
↑ Reed, L.J., Damuni, Z. and Merryfield, M.L. (1985). "Regulation of mammalian pyruvate and branched-chain α-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation". Curr. Top. Cell. Regul. 27: 41–49. PMID 3004826.

External links

(3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring))-phosphatase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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