1,4-dihydroxy-2-naphthoyl-CoA hydrolase

1,4-dihydroxy-2-naphthoyl-CoA hydrolase
Identifiers
EC number	3.1.2.28
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

1,4-dihydroxy-2-naphthoyl-CoA hydrolase (EC 3.1.2.28) is an enzyme with systematic name 1,4-dihydroxy-2-naphthoyl-CoA hydrolase.^[1][2][3] This enzyme catalyses the following chemical reaction

1,4-dihydroxy-2-naphthoyl-CoA + H₂O $\rightleftharpoons$ 1,4-dihydroxy-2-naphthoate + CoA

This enzyme participates in the biosynthesis of menaquinones, phylloquinone, and several plant pigments.

References

1. Widhalm, J.R., van Oostende, C., Furt, F. and Basset, G.J. (2009). "A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K₁". Proc. Natl. Acad. Sci. USA 106: 5599–5603. doi:10.1073/pnas.0900738106. PMID 19321747.
2. Muller, W and Leistner, E (1976). "1,4-naphthoquinone, an intermediate in juglone (5-hydroxy-1,4-naphthoquinone) biosynthesis". Phytochemistry 15: 407–410. doi:10.1016/s0031-9422(00)86833-8.
3. Eichinger D, Bacher A., Zenk M.H. and Eisenreich W. (1999). "Quantitative assessment of metabolic flux by ¹³C NMR analysis. Biosynthesis of anthraquinones in Rubia tinctorum". J. Am. Chem. Soc. 121: 7469–7475. doi:10.1021/ja990622o.

External links

• 1,4-dihydroxy-2-naphthoyl-CoA hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)