Acetylajmaline esterase

Acetylajmaline esterase
Identifiers
EC number	3.1.1.80
CAS number	110183-46-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Acetylajmaline esterase (EC 3.1.1.80, AAE, 2beta(R)-17-O-acetylajmalan:acetylesterase, acetylajmalan esterase) is an enzyme with systematic name 17-O-acetylajmaline O-acetylhydrolase.^[1][2] This enzyme catalyses the following chemical reaction

(1) 17-O-acetylajmaline + H₂O $\rightleftharpoons$ ajmaline + acetate

(2) 17-O-acetylnorajmaline + H₂O $\rightleftharpoons$ norajmaline + acetate

This plant enzyme mediates the last stages in the biosynthesis of the indole alkaloid ajmaline.

References

1. Polz, L., Schübel, H. and Stöckigt, J. (1987). "Characterization of 2β(R)-17-O-acetylajmalan:acetylesterase—a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid ajmaline". Z. Naturforsch. C 42 (4): 333–342. PMID 2955586.
2. Ruppert, M., Woll, J., Giritch, A., Genady, E., Ma, X. and Stöckigt, J. (2005). "Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system". Planta 222: 888–898. doi:10.1007/s00425-005-0031-0. PMID 16133216.

External links

• Acetylajmaline esterase at the US National Library of Medicine Medical Subject Headings (MeSH)