Actinomycin lactonase
| actinomycin lactonase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.1.1.39 | ||||||||
| CAS number | 37288-09-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, an actinomycin lactonase (EC 3.1.1.39) is an enzyme that catalyzes the chemical reaction
- actinomycin + H2O
actinomycinic monolactone
Thus, the two substrates of this enzyme are actinomycin and H2O, whereas its product is actinomycinic monolactone.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is actinomycin lactonohydrolase.
References
- Hou CT, Perlman D (1970). "Microbial transformations of peptide antibiotics. V. Purification and properties of the actinomycin lactonase from Actinoplanes missouriensis". J. Biol. Chem. 245 (6): 1289–95. PMID 4191854.
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