Collagen, type XV, alpha 1

Collagen, type XV, alpha 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3N3F​
Identifiers
Symbols	COL15A1 ; FLJ38566
External IDs	OMIM: 120325 MGI: 88449 HomoloGene: 1396 GeneCards: COL15A1 Gene
Gene ontology Molecular function • extracellular matrix structural constituent Cellular component • extracellular region • collagen type XV trimer • extracellular space • endoplasmic reticulum lumen • integral component of membrane • extracellular matrix • extracellular exosome Biological process • angiogenesis • cell adhesion • signal transduction • extracellular matrix disassembly • cell differentiation • extracellular matrix organization • collagen catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1306	12819
Ensembl	ENSG00000204291	ENSMUSG00000028339
UniProt	P39059	O35206
RefSeq (mRNA)	NM_001855	NM_009928
RefSeq (protein)	NP_001846	NP_034058
Location (UCSC)	Chr 9: 98.94 – 99.07 Mb	Chr 4: 47.21 – 47.31 Mb
PubMed search

Collagen alpha-1(XV) chain is a protein that in humans is encoded by the COL15A1 gene.^[1][2]

This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.^[2]

References

1. Huebner K, Cannizzaro LA, Jabs EW, Kivirikko S, Manzone H, Pihlajaniemi T, Myers JC (Dec 1992). "Chromosomal assignment of a gene encoding a new collagen type (COL15A1) to 9q21 --> q22". Genomics 14 (2): 220–4. doi:10.1016/S0888-7543(05)80209-5. PMID 1427836.
2. "Entrez Gene: COL15A1 collagen, type XV, alpha 1".

Further reading

• Myers JC, Kivirikko S, Gordon MK; et al. (1992). "Identification of a previously unknown human collagen chain, alpha 1(XV), characterized by extensive interruptions in the triple-helical region.". Proc. Natl. Acad. Sci. U.S.A. 89 (21): 10144–8. doi:10.1073/pnas.89.21.10144. PMC 50294. PMID 1279671.
• Kivirikko S, Heinämäki P, Rehn M; et al. (1994). "Primary structure of the alpha 1 chain of human type XV collagen and exon-intron organization in the 3' region of the corresponding gene.". J. Biol. Chem. 269 (7): 4773–9. PMID 8106446.
• Muragaki Y, Abe N, Ninomiya Y; et al. (1994). "The human alpha 1(XV) collagen chain contains a large amino-terminal non-triple helical domain with a tandem repeat structure and homology to alpha 1(XVIII) collagen.". J. Biol. Chem. 269 (6): 4042–6. PMID 8307960.
• Myers JC, Dion AS, Abraham V, Amenta PS (1997). "Type XV collagen exhibits a widespread distribution in human tissues but a distinct localization in basement membrane zones.". Cell Tissue Res. 286 (3): 493–505. doi:10.1007/s004410050719. PMID 8929352.
• Hägg PM, Hägg PO, Peltonen S; et al. (1997). "Location of type XV collagen in human tissues and its accumulation in the interstitial matrix of the fibrotic kidney.". Am. J. Pathol. 150 (6): 2075–86. PMC 1858337. PMID 9176399.
• Hägg PM, Muona A, Liétard J; et al. (1998). "Complete exon-intron organization of the human gene for the alpha1 chain of type XV collagen (COL15A1) and comparison with the homologous COL18A1 gene.". J. Biol. Chem. 273 (28): 17824–31. doi:10.1074/jbc.273.28.17824. PMID 9651385.
• Ramchandran R, Dhanabal M, Volk R; et al. (1999). "Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin.". Biochem. Biophys. Res. Commun. 255 (3): 735–9. doi:10.1006/bbrc.1999.0248. PMID 10049780.
• Li D, Clark CC, Myers JC (2000). "Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells.". J. Biol. Chem. 275 (29): 22339–47. doi:10.1074/jbc.M000519200. PMID 10791950.
• Nishi M, Mizushima A, Nakagawara K, Takeshima H (2000). "Characterization of human junctophilin subtype genes.". Biochem. Biophys. Res. Commun. 273 (3): 920–7. doi:10.1006/bbrc.2000.3011. PMID 10891348.
• Eklund L, Muona A, Liétard J, Pihlajaniemi T (2001). "Structure of the mouse type XV collagen gene, Col15a1, comparison with the human COL15A1 gene and functional analysis of the promoters of both genes.". Matrix Biol. 19 (6): 489–500. doi:10.1016/S0945-053X(00)00090-1. PMID 11068203.
• Tomono Y, Naito I, Ando K; et al. (2002). "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed in specialized basement membranes.". Cell Struct. Funct. 27 (1): 9–20. doi:10.1247/csf.27.9. PMID 11937714.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Myers JC, Amenta PS, Dion AS; et al. (2007). "The molecular structure of human tissue type XV presents a unique conformation among the collagens.". Biochem. J. 404 (3): 535–44. doi:10.1042/BJ20070201. PMC 1896284. PMID 17355226.