Carboxylesterase 3

Carboxylesterase 3
Identifiers
Symbols	CES3 ; ES31
External IDs	OMIM: 605279 MGI: 2148202 HomoloGene: 84407 GeneCards: CES3 Gene
EC number	3.1.1.1
Gene ontology Molecular function • sterol esterase activity • triglyceride lipase activity Cellular component • extracellular space • endoplasmic reticulum lumen • extracellular exosome Biological process • lipid catabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23491	13909
Ensembl	ENSG00000172828	ENSMUSG00000062181
UniProt	Q6UWW8	Q8VCU1
RefSeq (mRNA)	NM_001185176	NM_001159415
RefSeq (protein)	NP_001172105	NP_001152887
Location (UCSC)	Chr 16: 66.96 – 66.98 Mb	Chr 8: 105.08 – 105.09 Mb
PubMed search

Carboxylesterase 3 is an enzyme that in humans is encoded by the CES3 gene.^[1][2][3][4]

Function

Carboxylesterase 3 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system.^[4]

References

1. Mori M, Hosokawa M, Ogasawara Y, Tsukada E, Chiba K (Oct 1999). "cDNA cloning, characterization and stable expression of novel human brain carboxylesterase". FEBS Lett 458 (1): 17–22. doi:10.1016/S0014-5793(99)01111-4. PMID 10518925.
2. Sanghani SP, Quinney SK, Fredenburg TB, Sun Z, Davis WI, Murry DJ, Cummings OW, Seitz DE, Bosron WF (Oct 2003). "Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis". Clin Cancer Res 9 (13): 4983–91. PMID 14581373.
3. Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF (Apr 2004). "Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3". Drug Metab Dispos 32 (5): 505–11. doi:10.1124/dmd.32.5.505. PMID 15100172.
4. "Entrez Gene: CES3 carboxylesterase 3 (brain)".

Further reading

• Lee CV, Hymowitz SG, Wallweber HJ; et al. (2006). "Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.". Blood 108 (9): 3103–11. doi:10.1182/blood-2006-03-011031. PMID 16840730.
• Hassel S, Eichner A, Yakymovych M; et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.". Proteomics 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Venter JC, Adams MD, Myers EW; et al. (2001). "The sequence of the human genome.". Science 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
• Aida K, Moore R, Negishi M (1993). "Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse liver.". Biochim. Biophys. Acta 1174 (1): 72–4. doi:10.1016/0167-4781(93)90093-s. PMID 7916639.