2',3'-cyclic-nucleotide 2'-phosphodiesterase

2',3'-cyclic-nucleotide 2'-phosphodiesterase
Identifiers
EC number	3.1.4.16
CAS number	9037-18-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) is an enzyme that catalyzes the chemical reaction

nucleoside 2',3'-cyclic phosphate + H₂O $\rightleftharpoons$ nucleoside 3'-phosphate

Thus, the two substrates of this enzyme are nucleoside 2',3'-cyclic phosphate and H₂O, whereas its product is nucleoside 3'-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase. Other names in common use include ribonucleoside 2',3'-cyclic phosphate diesterase, 2',3 '-cyclic AMP phosphodiesterase, 2',3'-cyclic nucleotidase, cyclic 2',3'-nucleotide 2'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic AMP 2'-phosphohydrolase, cyclic phosphodiesterase:3'-nucleotidase, 2',3'-cyclic nucleotide phosphohydrolase, 2':3'-cyclic phosphodiesterase, and 2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase. This enzyme participates in purine metabolism and pyrimidine metabolism.

References

• ANRAKU Y (1964). "A NEW CYCLIC PHOSPHODIESTERASE HAVING A 3'-NUCLEOTIDASE ACTIVITY FROM ESCHERICHIA COLI B. I. PURIFICATION AND SOME PROPERTIES OF THE ENZYME". J. Biol. Chem. 239: 3412–9. PMID 14245396.
• ANRAKU Y (1964). "A NEW CYCLIC PHOSPHODIESTERASE HAVING A 3'-NUCLEOTIDASE ACTIVITY FROM ESCHERICHIA COLI B. II. FURTHER STUDIES ON SUBSTRATE SPECIFICITY AND MODE OF ACTION OF THE ENZYME". J. Biol. Chem. 239: 3420–4. PMID 14245397.
• Center MS, Behal FJ (1968). "A cyclic phosphodiesterase with 3'-nucleotidase activity from Proteus mirabilis". J. Biol. Chem. 243 (1): 138–43. PMID 4295113.
• Olafson RW, Drummond GI, Lee JF (1969). "Studies on 2',3'-cyclic nucleotide-3'-phosphohydrolase from brain". Can. J. Biochem. 47 (10): 961–6. doi:10.1139/o69-151. PMID 4310670.
• Unemoto T, Hayashi M (1969). "Chloride ion as a modifier of 2',3'-cyclic phosphodiesterase purified from halophilic Vibrio alginolyticus". Biochim. Biophys. Acta 171 (1): 89–102. doi:10.1016/0005-2744(69)90108-9. PMID 4303200.