D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase

D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase (EC 3.1.3.82, gmhB (gene), yaeD (gene)) is an enzyme with systematic name D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphohydrolase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H₂O

\rightleftharpoons

D-glycero-beta-D-manno-heptose 1-phosphate + phosphate

The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose.

References

↑ Kneidinger, B., Marolda, C., Graninger, M., Zamyatina, A., McArthur, F., Kosma, P., Valvano, M.A. and Messner, P. (2002). "Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli". J. Bacteriol. 184: 363–369. doi:10.1128/jb.184.2.363-369.2002. PMID 11751812.
↑ Valvano, M.A., Messner, P. and Kosma, P. (2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides". Microbiology 148: 1979–1989. doi:10.1099/00221287-148-7-1979. PMID 12101286.
↑ Wang, L., Huang, H., Nguyen, H.H., Allen, K.N., Mariano, P.S. and Dunaway-Mariano, D. (2010). "Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)". Biochemistry 49: 1072–1081. doi:10.1021/bi902018y. PMID 20050615.

External links

D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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