Poly(A)-specific ribonuclease

Poly(A)-specific ribonuclease

PDB rendering based on 1whv.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PARN ; DAN; DKCB6; PFBMFT4
External IDs OMIM: 604212 MGI: 1921358 HomoloGene: 31098 GeneCards: PARN Gene
EC number 3.1.13.4
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5073 74108
Ensembl ENSG00000140694 ENSMUSG00000022685
UniProt O95453 Q8VDG3
RefSeq (mRNA) NM_001134477 NM_028761
RefSeq (protein) NP_001127949 NP_083037
Location (UCSC) Chr 16:
14.44 – 14.63 Mb
Chr 16:
13.54 – 13.67 Mb
PubMed search

Poly(A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene.[1][2]

Function

Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. The amino acid sequence of poly(A)-specific ribonuclease shows homology to the RNase D family of 3'-exonucleases. The protein appears to be localized in both the nucleus and the cytoplasm. It is not stably associated with polysomes or ribosomal subunits.[2]

References

  1. Buiting K, Korner C, Ulrich B, Wahle E, Horsthemke B (May 2000). "The human gene for the poly(A)-specific ribonuclease (PARN) maps to 16p13 and has a truncated copy in the Prader-Willi/Angelman syndrome region on 15q11→q13". Cytogenet Cell Genet 87 (1–2): 125–31. doi:10.1159/000015378. PMID 10640832.
  2. 1 2 "Entrez Gene: PARN poly(A)-specific ribonuclease (deadenylation nuclease)".

Further reading

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