Serratia marcescens nuclease

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Serratia marcescens nuclease (EC 3.1.30.2, endonuclease (Serratia marcescens), barley nuclease, plant nuclease I, nucleate endonuclease) is an enzyme.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

Endonucleolytic cleavage to 5'-phosphomononucleotide and 5'-phosphooligonucleotide end-products

Hydrolyses double- or single-stranded substrate.

References

↑ Mikulski, A.J. and Laskowski, M. (1970). ", Sr. Mung bean nuclease I. 3. Purification procedure and (3′) ω monophosphatase activity". J. Biol. Chem. 245: 5026–5031. PMID 4319109.
↑ Stevens, A. and Hilmoe, R.J. (1960). "Studies on a nuclease from Azotobacter agilis. I. Isolation and mode of action". J. Biol. Chem. 235: 3016–3022.
↑ Stevens, A. and Hilmoe, R.J. (1960). "Studies on a nuclease from Azotobacter agilis. II. Hydrolysis of ribonucleic and deoxyribonucleic acids". J. Biol. Chem. 235: 3023–3027.
↑ Wechter, W.J., Mikulski, A.J. and Laskowski, M. (1968). ", Sr. Gradation of specificity with regard to sugar among nucleases". Biochem. Biophys. Res. Commun. 30: 318–322. doi:10.1016/0006-291x(68)90453-1. PMID 4296679.

External links

Serratia marcescens nuclease at the US National Library of Medicine Medical Subject Headings (MeSH)
Serratia marcescens endonuclease at Protean Ltd., highly active

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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