Exonuclease VII

Exonuclease VII, large subunit
Identifiers
Symbol	Exonuc_VII_L
Pfam	PF02601
InterPro	IPR020579
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Exonuclease VII small subunit
crystal structure of exodeoxyribonuclease vii small subunit (np_881400.1) from bordetella pertussis at 2.40 a resolution
Identifiers
Symbol	Exonuc_VII_S
Pfam	PF02609
InterPro	IPR003761
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, exonuclease VII (EC 3.1.11.6, Escherichia coli exonuclease VII, E. coli exonuclease VII, endodeoxyribonuclease VII, Exodeoxyribonuclease VII) is a bacterial exonuclease enzyme.^[1][2] It is composed of two nonidentical subunits; one large subunit and 4 small ones.^[3] Exonuclease VII catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield 5'-phosphomononucleotides. The large subunit also contains an N-terminal OB-fold domain that binds to nucleic acids.

References

1. Chase, J.W. and Richardson, C.C. (1974). "Ribonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4545–4552. PMID 4602029.
2. Chase, J.W. and Richardson, C.C. (1974). "Exonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4553–4561. PMID 4602030.
3. Vales LD, Rabin BA, Chase JW (August 1982). "Subunit structure of Escherichia coli exonuclease VII". J. Biol. Chem. 257 (15): 8799–805. PMID 6284744.

This article incorporates text from the public domain Pfam and InterPro IPR020579

This article incorporates text from the public domain Pfam and InterPro IPR003761