Fluoroacetyl-CoA thioesterase

Fluoroacetyl-CoA thioesterase (EC 3.1.2.29) is an enzyme with systematic name fluoroacetyl-CoA hydrolase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

fluoroacetyl-CoA + H₂O

\rightleftharpoons

fluoroacetate + CoA

Fluoroacetate is extremely toxic.

References

↑ Meyer, J.J.M., Grobbelaar, N., Vleggaar, R. and Louw, A.I. (1992). "Fluoroacetyl-coenzyme-A hydrolase-like activity in Dichapetalum cymosum". J. Plant Physiol. 139: 369–372. doi:10.1016/s0176-1617(11)80352-4.
↑ Huang, F., Haydock, S.F., Spiteller, D., Mironenko, T., Li, T.L., O'Hagan, D., Leadlay, P.F. and Spencer, J.B. (2006). "The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A". Chem. Biol. 13: 475–484. doi:10.1016/j.chembiol.2006.02.014. PMID 16720268.
↑ Dias, M.V., Huang, F., Chirgadze, D.Y., Tosin, M., Spiteller, D., Dry, E.F., Leadlay, P.F., Spencer, J.B. and Blundell, T.L. (2010). "Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK". J. Biol. Chem. 285: 22495–22504. doi:10.1074/jbc.m110.107177. PMID 20430898.

External links

Fluoroacetyl-CoA thioesterase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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