| Name | 
North or east end | 
South or west end | 
U.S. Highways (approximate, based on 1926 plan and later additions) | 
Notes | 
| Albert Pike Highway | 
Hot Springs, Arkansas | 
Colorado Springs, Colorado | 
US 270, US 64, US 183, US 154, US 50, US 85 | 
| Arrowhead Trail | 
Salt Lake City, Utah | 
Los Angeles, California | 
US 91 | 
| Atlantic Highway | 
Calais, Maine | 
Miami, Florida | 
US 1, US 25, US 17, US 1 | 
| Atlantic-Pacific Highway | 
New York, New York | 
Los Angeles, California | 
US 1, US 211, US 15, US 33, US 60, US 52, US 460, US 50, US 54, US 70, US 60 | 
| Atlantic Yellowstone Pacific Highway | 
Chicago, Illinois | 
Sioux Falls, South Dakota | 
US 20, US 218, US 18 | 
| Baltimore Pike | 
Baltimore, Maryland | 
Philadelphia, Pennsylvania | 
 | 
| Bankhead Highway | 
Washington, D.C. | 
San Diego, California | 
US 1, US 15, US 70, US 170, US 29, US 78, US 70, US 67, US 80 | 
| Bee Line Highway | 
Chicago, Illinois | 
New Orleans, Louisiana | 
 | 
| Ben Hur Highway | 
St. Louis, Missouri | 
Fort Dodge, Iowa | 
 | 
| Black and Yellow Trail | 
Chicago, Illinois | 
Yellowstone National Park | 
US 41, US 16, US 14, US 16, US 20 | 
| Blackhawk Highway | 
Dixon, Illinois | 
Beloit, Wisconsin | 
IL 2, IL 251, US 51 | 
| California-Banff Bee Line | 
 | 
 | 
 | 
| Cannon Ball Route | 
Chicago, Illinois | 
Hannibal, Missouri | 
 | 
| Capital Route | 
Omaha, Nebraska | 
Austin, Texas | 
 | 
| Chicago, Kansas City and Gulf Highway | 
Chicago, Illinois | 
Galveston, Texas | 
 | 
| Colorado to Gulf Highway | 
Denver, Colorado | 
Galveston, Texas and Brownsville, Texas | 
US 85, US 385, US 370, US 81, US 181 | 
| Columbia River Highway | 
Pendleton, Oregon | 
Portland, Oregon | 
US 30 | 
| Cooley Highway | 
Grand Rapids, Minnesota | 
Sisseton, South Dakota | 
 | 
| Cornhusker Highway | 
Sioux City, Iowa | 
Oklahoma City, Oklahoma | 
 | 
| Custer Battlefield Highway | 
Omaha, Nebraska | 
Glacier National Park | 
US 75, US 16, US 116, US 87E, US 87 | 
| Dallas-Canadian-Denver Highway | 
Boulder, Colorado | 
Galveston, Texas | 
US 85, US 50, US 83, US 70, US 77 | 
| Daniel Webster Highway | 
 | 
 | 
 | 
| Detroit-Lincoln-Denver Highway | 
Detroit, Michigan | 
Denver, Colorado | 
US 12, US 32, US 38 | 
| Dixie Highway | 
Chicago, Illinois and Sault Ste. Marie, Michigan | 
Miami, Florida | 
Illinois 1, US 136, US 31, Indiana 37, US 150, US 31W | 
| Dixie Bee Line | 
Chicago, Illinois | 
Nashville, Tennessee | 
US 41, US 241 | 
| Dixie Overland Highway | 
Savannah, Georgia | 
San Diego, California | 
US 80, US 84, US 380, US 366, US 80 | 
| Evergreen National Highway | 
Victoria, British Columbia | 
El Paso, Texas | 
US 99, US 10, US 97, US 410, US 95, US 30, US 30N, US 91, US 95, US 66 | 
| Egyptian Trail | 
Chicago, Illinois | 
Cairo, Illinois | 
 | 
| Florida Short Route | 
 | 
 | 
 | 
| George Washington National Highway | 
Savannah, Georgia | 
Seattle, Washington | 
 | 
| Geysers-to-Glaciers Highway | 
Glacier National Park | 
Yellowstone National Park | 
US 89 W from West Yellowstone to Shelby, Montana; US 2 from Shelby to Cut Bank, Montana; and MT 213 from Cut Bank to the Canadian border[1] | 
| Glacier to Gulf Motorway | 
Calgary, Alberta | 
Tampico, Mexico | 
 | 
| Glacier Trail | 
Seattle, Washington | 
Jacksonville, Florida | 
 | 
| Grant Highway | 
Chicago, Illinois | 
Portland, Oregon | 
US 20 | 
| Great White Way | 
Davenport, Iowa | 
Council Bluffs, Iowa | 
 | 
| International Peace Highway | 
Quebec, Quebec and Rouses Point, New York | 
Laredo, Texas and Mexico City, Mexico | 
 | 
| Jackson Highway | 
Chicago, Illinois | 
New Orleans, Louisiana | 
US 152, US 52, US 31, US 168, US 68, US 31, US 43, US 45, US 11 | 
| Jefferson Highway | 
Winnipeg, Manitoba | 
New Orleans, Louisiana | 
US 59, US 2, US 71, US 10N, US 10, US 65, US 69, US 71/US 73E, US 73, US 75, US 69, US 67, US 271, US 80, US 171, US 71, US 61 | 
| Jefferson Davis National Highway | 
Washington, D.C. | 
San Diego, California | 
US 1, US 278, US 29, US 80, US 43, US 90, US 96, US 277, US 90 | 
| King of Trails | 
Winnipeg, Manitoba | 
Galveston, Texas and Brownsville, Texas | 
US 75/US 81, US 75/US 77, US 75, US 73, US 73E, US 50, US 73W, US 75, US 77, US 81, US 181, US 96 | 
| Lackawanna Trail | 
Binghamton, New York | 
Delaware, New Jersey | 
US 11,[2] US 611[3]  | 
| Lakes to Gulf Highway | 
Duluth, Minnesota | 
Galveston, Texas | 
 | 
| Lakes-to-Sea Highway | 
Atlantic City, New Jersey | 
Erie, Pennsylvania | 
US 30, US 120, US 22, US 322, US 19 | 
| Lee Highway | 
New York, New York | 
San Francisco, California | 
US 1, US 211, US 11, US 72, US 70, US 366, US 80, US 180, US 80, US 101 | 
| Lewis and Clark Highway | 
Missoula, Montana | 
Lewiston, Idaho | 
 | 
| Liberty Highway | 
New York, New York | 
Cleveland, Ohio | 
New Jersey 4, New Jersey 17, New York 17, New York 430, New York 394, US 20[4] | 
| Lincoln Highway | 
New York, New York | 
San Francisco, California | 
US 1, US 30, US 40, US 93, US 50, US 99, US 48  | 
| Logan-Lee Highway | 
Rock Island, Illinois | 
Paducah, Kentucky | 
US 67, Illinois 3 | 
| Lone Star Route | 
Chicago, Illinois | 
Lake Charles, Louisiana (earlier Brownsville, Texas) | 
US 66, US 67, US 63, US 165 | 
| Lone Star Trail | 
St. Augustine, Florida | 
Los Angeles, California | 
US 1, US 90, US 84, US 67, US 290, US 80 | 
| Magnolia Route | 
 | 
 | 
 | 
| Meridian Highway | 
Winnipeg, Manitoba | 
Mexico City, Mexico | 
US 81 | 
| Mississippi River Scenic Highway | 
Winnipeg, Manitoba and Port Arthur, Ontario | 
Fort Myers, Florida and Port Arthur, Texas | 
US 75, US 2, US 71, US 10N, US 10, US 61, US 55, US 61, US 90; US 49E, US 49, US 98, US 90, US 19, US 41 | 
| Mississippi Valley Highway | 
Ely, Minnesota | 
Gulfport, Mississippi (earlier New Orleans, Louisiana) | 
US 53, US 61, US 55, US 161, US 67, US 51, US 45, US 11, US 49 | 
Earlier known as the Burlington Way | 
| National Old Trails Road | 
Washington, D.C. and Baltimore, Maryland | 
Los Angeles, California | 
US 240/US 40, US 40, US 50N, US 50, US 350, US 85, US 70, US 66 | 
| National Park-to-Park Highway | 
Loop connecting National Parks | 
 | 
US 99, US 48, US 40, US 99E, US 99, US 10, US 195, US 95, US 2, US 87, US 87W, US 20, US 185, US 85, US 50, US 285, US 450, US 550, US 64, US 666, US 66 | 
| National Parks Highway | 
Boston, Massachusetts and New York, New York | 
Seattle, Washington | 
 | 
Also known as the Northwest Trail | 
| National Roosevelt Midland Trail | 
Washington, D.C. and Newport News, Virginia (earlier Oyster Bay, New York) | 
Los Angeles, California | 
US 60, US 150, US 50, US 40, US 40N, US 40, US 40S, US 50, US 6 | 
| National White Way | 
 | 
 | 
 | 
| New Santa Fe Trail | 
Kansas City, Mo. | 
Los Angeles | 
US 50, US 350, US 85, US 66 | 
| Old Oregon Trail | 
Independence, Missouri | 
Seaside, Oregon and Olympia, Washington | 
US 40, US 30, US 26, US 20, US 87E, US 30N, US 30 | 
| Old Spanish Trail | 
St. Augustine, Florida | 
San Diego, California | 
US 1, US 90, US 80 | 
| Ozark Trails | 
Kansas City, Missouri, Hannibal, Missouri, St. Louis, Missouri, and Memphis, Tennessee | 
Denver, Colorado, Las Vegas, New Mexico, and El Paso, Texas | 
 | 
| Pacific Highway | 
Vancouver, British Columbia | 
San Diego, California | 
US 99, US 40, US 101 | 
| Pershing Way | 
Winnipeg, Manitoba | 
New Orleans, Louisiana | 
 | 
| Pikes Peak Ocean to Ocean Highway | 
New York, New York | 
Los Angeles, California (earlier San Francisco, California) | 
US 22, US 250, US 36, US 136, US 36, US 40N, US 40S, US 50, US 91 | 
Also known as the Pershing Transport Route | 
| Puget Sound-to-Gulf Highway | 
 | 
 | 
 | 
| Red Ball Route | 
 | 
 | 
 | 
| River-to-River Road | 
Davenport, Iowa | 
Council Bluffs, Iowa | 
 | 
| Southern National Highway | 
 | 
 | 
 | 
| Southwest Trail | 
Chicago, Illinois | 
El Paso, Texas | 
US 32, US 65, US 50S, US 81, US 160, US 281, US 60, US 366 | 
| Susquehanna Trail | 
Buffalo, New York | 
Washington, D.C. | 
US 20, US 15, US 111/US 240 | 
| Theodore Roosevelt International Highway | 
Portland, Maine | 
Portland, Oregon | 
US 302, US 2, US 11, US 104, US 23, US 2, US 95, US 195, US 295, US 410, US 30 | 
| Three C Highway | 
Cleveland, Ohio | 
Cincinnati, Ohio | 
US 42 | 
| Transprovincial Highway | 
Ottawa | 
Toronto | 
 | 
Later Ontario Highway 2 and Ontario Highway 15 | 
| Victory Highway | 
New York, New York | 
San Francisco, California | 
US 1, US 40, US 40S, US 83, US 40N, US 40 | 
| White River Trail | 
Springfield, Missouri | 
Ponca City, Oklahoma | 
 | 
| White-way 7 Highway | 
Chicago, Illinois | 
Omaha, Nebraska | 
US 32 | 
In Iowa, created from segments of the River to River Road from Davenport to Redfield, and the Great White Way from Dexter to Council Bluffs. | 
| William Penn Highway | 
New York, New York | 
Pittsburgh, Pennsylvania | 
US 22 | 
| Yellowstone Highway | 
Denver, Colorado | 
Yellowstone National Park | 
 | 
| Yellowstone Trail | 
Plymouth, Massachusetts | 
Seattle, Washington | 
US 20, US 30, US 41, US 110, US 10, US 212, US 12, US 10, US 195, US 295, US 410, US 97, US 10 |