Glycerophosphocholine phosphodiesterase

glycerophosphocholine phosphodiesterase
Identifiers
EC number	3.1.4.2
CAS number	9025-85-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a glycerophosphocholine phosphodiesterase (EC 3.1.4.2) is an enzyme that catalyzes the chemical reaction

sn-glycero-3-phosphocholine + H₂O $\rightleftharpoons$ choline + sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are sn-glycero-3-phosphocholine and H₂O, whereas its two products are choline and sn-glycerol 3-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is sn-glycero-3-phosphocholine glycerophosphohydrolase. Other names in common use include glycerophosphinicocholine diesterase, glycerylphosphorylcholinediesterase, sn-glycero-3-phosphorylcholine diesterase, glycerolphosphorylcholine phosphodiesterase, and glycerophosphohydrolase. This enzyme participates in glycerophospholipid metabolism.

References

• Dawson RMC (1956). "Liver glycerylphosphorylcholine diesterase". Biochem. J. 62: 689–693.
• HAYAISHI O, KORNBERG A (1954). "Metabolism of phospholipides by bacterial enzymes". J. Biol. Chem. 206 (2): 647–63. PMID 13143024.
• Webster GR, Marples EA and Thompson RHS (1957). "Glycerylphosphorylcholine diesterase activity in nervous tissue". Biochem. J. 65 (2): 374–377. PMC 1199879. PMID 13403918.