HLA-B44

HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B44
Alleles	B*4401, 4402, 4403 . .
Structure (See HLA-B)
Shared data
Locus	chr.6 6p21.31

HLA-B44 (B44) is an HLA-B serotype. The serotype identifies the B*44 gene-allele protein products of HLA-B.^[1]

B44 is a split antigen of the broad antigen B12, and is a sister type of B45.

Serotype

Serotypes B44, B12, and B45 recognition of the
HLA B*44 gene products^[2]

B*44	B44	B12	B45	Sample
allele	%	%	%	size (N)
*4402	98			6959
*4403	94			2854
*4404	65			42
*4405	92			130
*4406	44			9
B*4401 was shown to be B*4402 after errors corrected.
Alleles link-out to IMGT/HLA Database at EBI

Disease

HLA-B44 increases recurrent sinopulmonary infections.^[3] Protective effects: HLA-B44 appears to be protective against autoimmune lymphoproliferative syndrome in patients with C95 defect (ALPS type Ia).^[4] B44 may be a cofactor in ankylosing spondylitis^[5]

References

1. Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
2. derived from IMGT/HLA
3. Johnston DT, Mehaffey G, Thomas J, et al. (June 2006). "Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI)". Clin. Immunol. 119 (3): 346–50. doi:10.1016/j.clim.2006.02.001. PMID 16542878.
4. Vacek MM, Schäffer AA, Davis J, et al. (January 2006). "HLA B44 is associated with decreased severity of autoimmune lymphoproliferative syndrome in patients with CD95 defects (ALPS type Ia)". Clin. Immunol. 118 (1): 59–65. doi:10.1016/j.clim.2005.09.006. PMID 16257267.
5. Purrmann J, Zeidler H, Bertrams J, et al. (November 1988). "HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44". J. Rheumatol. 15 (11): 1658–61. PMID 3266250.