HPSE2

Heparanase 2 (inactive)
Identifiers
Symbols	HPSE2 ; HPA2; HPR2; UFS; UFS1
External IDs	OMIM: 613469 HomoloGene: 19680 GeneCards: HPSE2 Gene
Gene ontology Molecular function • heparanase activity • heparan sulfate proteoglycan binding Cellular component • proteinaceous extracellular matrix • intracellular • plasma membrane Biological process • carbohydrate metabolic process • glycosaminoglycan catabolic process • biological_process • glycosaminoglycan metabolic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	60495	545291
Ensembl	ENSG00000172987	ENSMUSG00000074852
UniProt	Q8WWQ2	B2RY83
RefSeq (mRNA)	NM_001166244	NM_001081257
RefSeq (protein)	NP_001159716	NP_001074726
Location (UCSC)	Chr 10: 98.46 – 99.24 Mb	Chr 19: 42.79 – 43.39 Mb
PubMed search

Heparanase-2 is an enzyme that in humans is encoded by the HPSE2 gene.^[1][2]

It may be associated with urofacial syndrome.^[3]

References

1. McKenzie E, Tyson K, Stamps A, Smith P, Turner P, Barry R, Hircock M, Patel S, Barry E, Stubberfield C, Terrett J, Page M (Oct 2000). "Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member". Biochem Biophys Res Commun 276 (3): 1170–7. doi:10.1006/bbrc.2000.3586. PMID 11027606.
2. "Entrez Gene: HPSE2 heparanase 2".
3. Daly SB, Urquhart JE, Hilton E, et al. (June 2010). "Mutations in HPSE2 Cause Urofacial Syndrome". Am J Hum Genet 86 (6): 963–969. doi:10.1016/j.ajhg.2010.05.006. PMC 3032078. PMID 20560210.

Further reading

• D'Souza SS, Fazleabas AT, Banerjee P, et al. (2008). "Decidual heparanase activity is increased during pregnancy in the baboon (Papio anubis) and in in vitro decidualization of human stromal cells". Biol. Reprod. 78 (2): 316–23. doi:10.1095/biolreprod.107.063891. PMID 17989358.
• Bar-Sela G, Kaplan-Cohen V, Ilan N, et al. (2006). "Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival". Histopathology 49 (2): 188–93. doi:10.1111/j.1365-2559.2006.02469.x. PMID 16879396.
• Beckhove P, Helmke BM, Ziouta Y, et al. (2005). "Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis". Clin. Cancer Res. 11 (8): 2899–906. doi:10.1158/1078-0432.CCR-04-0664. PMID 15837740.
• Ogishima T, Shiina H, Breault JE, et al. (2005). "Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer". Clin. Cancer Res. 11 (3): 1028–36. PMID 15709168.
• Wang Z, Xu H, Jiang L, et al. (2005). "Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma". Mod. Pathol. 18 (2): 205–11. doi:10.1038/modpathol.3800282. PMID 15475937.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.