NEU2

Sialidase 2 (cytosolic sialidase)
PDB rendering based on 1snt.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1SNT​, 1SO7​, 1VCU​, 2F0Z​, 2F10​, 2F11​, 2F12​, 2F13​, 2F24​, 2F25​, 2F26​, 2F27​, 2F28​, 2F29​
Identifiers
Symbols	NEU2 ; SIAL2
External IDs	OMIM: 605528 MGI: 1344417 HomoloGene: 3927 ChEMBL: 3200 GeneCards: NEU2 Gene
EC number	3.2.1.18
Gene ontology Molecular function • catalytic activity • hydrolase activity, acting on glycosyl bonds • exo-alpha-(2->3)-sialidase activity • exo-alpha-(2->6)-sialidase activity • exo-alpha-(2->8)-sialidase activity Cellular component • cytoplasm • cytosol Biological process • sphingolipid metabolic process • glycosphingolipid metabolic process • positive regulation of myotube differentiation • small molecule metabolic process • response to ethanol • positive regulation of myoblast differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4759	23956
Ensembl	ENSG00000115488	ENSMUSG00000079434
UniProt	Q9Y3R4	Q9JMH3
RefSeq (mRNA)	NM_005383.2	NM_001160163.1
RefSeq (protein)	NP_005374.2	NP_001153635.1
Location (UCSC)	Chr 2: 233.9 – 233.9 Mb	Chr 1: 89.41 – 89.49 Mb
PubMed search

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.^[1][2][3]

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.^[3]

References

1. Monti E, Preti A, Rossi E, Ballabio A, Borsani G (Jun 1999). "Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases". Genomics 57 (1): 137–143. doi:10.1006/geno.1999.5749. PMID 10191093.
2. Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E (Jan 2004). "Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules". J Biol Chem 279 (5): 3169–3179. doi:10.1074/jbc.M308381200. PMID 14613940.
3. "Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)".

Further reading

• Li CY, Yu Q, Ye ZQ, et al. (2007). "A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir". Cell Res. 17 (4): 357–362. doi:10.1038/cr.2007.27. PMID 17426694.
• Chavas LM, Tringali C, Fusi P, et al. (2005). "Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition". J. Biol. Chem. 280 (1): 469–75. doi:10.1074/jbc.M411506200. PMID 15501818.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hart ML, Saifuddin M, Uemura K, et al. (2003). "High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1". AIDS Res. Hum. Retroviruses 18 (17): 1311–1317. doi:10.1089/088922202320886352. PMID 12487819.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bassi MT, Sperandeo MP, Incerti B, et al. (2000). "SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family". Genomics 62 (2): 297–303. doi:10.1006/geno.1999.5978. PMID 10610726.
• Monti E, Preti A, Nesti C, et al. (2000). "Expression of a novel human sialidase encoded by the NEU2 gene". Glycobiology 9 (12): 1313–1321. doi:10.1093/glycob/9.12.1313. PMID 10561456.
• Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. PMC 190813. PMID 8892864.
• Miyagi T, Konno K, Emori Y, et al. (1994). "Molecular cloning and expression of cDNA encoding rat skeletal muscle cytosolic sialidase". J. Biol. Chem. 268 (35): 26435–40. PMID 8253770.