NEU4
| Sialidase 4 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | NEU4 ; FLJ35928; MGC102757; MGC18222 | ||||||||||||
| External IDs | OMIM: 608527 MGI: 2661364 HomoloGene: 15433 ChEMBL: 4174 GeneCards: NEU4 Gene | ||||||||||||
| EC number | 3.2.1.18 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 129807 | 241159 | |||||||||||
| Ensembl | ENSG00000204099 | ENSMUSG00000034000 | |||||||||||
| UniProt | Q8WWR8 | Q8BZL1 | |||||||||||
| RefSeq (mRNA) | NM_001167599.1 | NM_173772.3 | |||||||||||
| RefSeq (protein) | NP_001161071.1 | NP_776133.1 | |||||||||||
| Location (UCSC) |
Chr 2: 242.75 – 242.76 Mb |
Chr 1: 95.92 – 95.92 Mb | |||||||||||
| PubMed search | |||||||||||||
Sialidase-4 is an enzyme that in humans is encoded by the NEU4 gene.[1]
Function
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.[1]
Interactions
NEU4 has been shown to interact with PLSCR1.[2]
References
- 1 2 "Entrez Gene: NEU4 sialidase 4".
- ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Further reading
- Comelli EM, Amado M, Lustig SR, Paulson JC (2004). "Identification and expression of Neu4, a novel murine sialidase.". Gene 321: 155–61. doi:10.1016/j.gene.2003.08.005. PMID 14637003.
- Monti E, Bassi MT, Bresciani R, Civini S, Croci GL, Papini N, Riboni M, Zanchetti G, Ballabio A, Preti A, Tettamanti G, Venerando B, Borsani G (2004). "Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family.". Genomics 83 (3): 445–53. doi:10.1016/j.ygeno.2003.08.019. PMID 14962670.
- Seyrantepe V, Landry K, Trudel S, Hassan JA, Morales CR, Pshezhetsky AV (2004). "Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells.". J. Biol. Chem. 279 (35): 37021–9. doi:10.1074/jbc.M404531200. PMID 15213228.
- Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
- Stamatos NM, Liang F, Nan X, Landry K, Cross AS, Wang LX, Pshezhetsky AV (2005). "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages.". FEBS J. 272 (10): 2545–56. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103.
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