Inositol-polyphosphate 5-phosphatase

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Inositol-polyphosphate 5-phosphatase (EC 3.1.3.56, type I inositol-polyphosphate phosphatase, inositol trisphosphate phosphomonoesterase, InsP3/Ins(1,3,4,5)P4 5-phosphatase, inosine triphosphatase, D-myo-inositol 1,4,5-triphosphate 5-phosphatase, D-myo-inositol 1,4,5-trisphosphate 5-phosphatase, L-myo-inositol 1,4,5-trisphosphate-monoesterase, inositol phosphate 5-phosphomonoesterase, inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase, Ins(1,4,5)P3 5-phosphatase, D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase, inositol 1,4,5-trisphosphate phosphatase, inositol polyphosphate-5-phosphatase, myo-inositol-1,4,5-trisphosphate 5-phosphatase, inositol-1,4,5-trisphosphate 5-phosphatase) is an enzyme with systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

(1) D-myo-inositol 1,4,5-trisphosphate + H₂O

\rightleftharpoons

myo-inositol 1,4-bisphosphate + phosphate

(2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H₂O

\rightleftharpoons

1D-myo-inositol 1,3,4-trisphosphate + phosphate

One mammalian isoform is known.

References

↑ Downes, C.P., Mussat, M.C. and Michell, R.H. (1982). "The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane". Biochem. J. 203: 169–177. PMID 6285891.
↑ Erneux, C., Lemos, M., Verjans, B., Vanderhaeghen, P., Delvaux, A. and Dumont, J.E. (1989). "Soluble and particulate Ins(1,4,5)P₃/Ins(1,3,4,5)P₄ 5-phosphatase in bovine brain". Eur. J. Biochem. 181: 317–322. doi:10.1111/j.1432-1033.1989.tb14726.x. PMID 2540972.
↑ Woscholski, R. and Parker, P.J. (2000). "Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates". In Cockcroft, S. Biology of Phosphoinositides. Oxford: Biology of Phosphoinositides. pp. 320–338.
↑ Verjans, B., De Smedt, F., Lecocq, R., Vanweyenberg, V., Moreau, C. and Erneux, C. (1994). "Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase". Biochem. J. 300: 85–90. PMID 8198557.

External links

Inositol-polyphosphate 5-phosphatase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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