Laudexium metilsulfate

Laudexium metilsulfate
Systematic (IUPAC) name
1-[(3,4-Dimethoxyphenyl)methyl]-2-[10-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]decyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium methyl sulfate
Clinical data
Routes of
administration		 IV
Legal status
Legal status
  • discontinued from clinical use
Pharmacokinetic data
Bioavailability 100% (IV)
Identifiers
CAS Number 3253-60-9 YesY
PubChem CID 18618
ChemSpider 17584 N
UNII D067KDG4NU N
Synonyms Laudolissin
Chemical data
Formula C54H80N2O16S2
Molar mass 1077.35 g/mol
 NYesY (what is this?)  (verify)

Laudexium metilsulfate is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Laudexium[1] is no longer used in clinical practice, though it was introduced clinically in the early 1950s. It has about half the potency, a slower onset of action and a duration of action much longer than that of d-tubocurarine.[2] As with all clinically established (as well as experimental agents) with a non-depolarizing mechanism of action, its pharmacological action can be antagonized by anticholinesterases.

The displacement of laudexium from clinical use was assured owing to recurrent reports of significant post-operative re-curarization.[3]

References

  1. ↑ Taylor EP (1952). "Synthetic neuromuscular blocking agents. Part II. Bis(quaternary ammonium salts) derived from laudanosine". J Chem Soc: 142–145. doi:10.1039/JR9520000142.
  2. ↑ Hunter AR (1955). "The action of laudexium in man and experimental animals". Br J Anaesth 27 (2): 73–79. doi:10.1093/bja/27.2.73. PMID 13230365.
  3. ↑ Collier HO, Macauley B (1952). "The pharmacological properties of "laudolissin" a long-acting curarizing agent". Br J Pharmacol Chemother 7 (3): 398–408. doi:10.1111/j.1476-5381.1952.tb00707.x. PMC: 1509112. PMID 12978243.

External links

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