Luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase

luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase
Identifiers
EC number	2.4.1.191
CAS number	115490-50-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase (EC 2.4.1.191) is an enzyme that catalyzes the chemical reaction

UDP-glucuronate + luteolin 7-O-beta-D-diglucuronide $\rightleftharpoons$ UDP + luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide]-4'-O-beta-D- glucuronide

Thus, the two substrates of this enzyme are UDP-glucuronate and luteolin 7-O-beta-D-diglucuronide, whereas its 4 products are UDP, luteolin, [[7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide]-4'-O-beta-D-]], and glucuronide.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase. Other names in common use include uridine diphosphoglucuronate-luteolin 7-O-diglucuronide, glucuronosyltransferase, UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase, UDPglucuronate:luteolin, 7-O-diglucuronide-4'-O-glucuronosyl-transferase, and LDT.

References

• Schulz M and Weissenbock G (1988). "3 specific UDP-glucuronate-flavone-glucuronosyl-transferases from primary leaves of Secale cereale". Phytochemistry 27 (5): 1261–1267. doi:10.1016/0031-9422(88)80175-4.