N-acetylgalactosamine-4-sulfatase

N-acetylgalactosamine-4-sulfatase
Identifiers
EC number 3.1.6.12
CAS number 55354-43-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

N-acetylgalactosamine-4-sulfatase (EC 3.1.6.12, chondroitinsulfatase, chondroitinase, arylsulfatase B, acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase) is an enzyme with systematic name N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase.[1][2][3] This enzyme catalyses the following chemical reaction

Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate

This enzazyme also acts on N-acetylglucosamine 4-sulfate.

References

  1. ↑ Farooqui, A.A. (1976). "The desulphation of hexosamine sulphates by arylsulphatase B". Experientia 32 (10): 1242–1244. doi:10.1007/BF01953071. PMID 976430.
  2. ↑ Gorham, S.D. and Cantz, M. (1978). "Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide". Hoppe-Seyler's Z. Physiol. Chem. 359 (12): 1811–1814. doi:10.1515/bchm2.1978.359.2.1811. PMID 738706.
  3. ↑ Tsuji, M., Nakanishi, Y., Habuchi, H., Ishihara, K. and Suzuki, S. (1980). "The common identity of UDP-N-acetylgalactosamine 4-sulfatase, nitrocatechol sulfatase (arylsulfatase), and chondroitin 4-sulfatase". Biochim. Biophys. Acta 612 (2): 373–383. doi:10.1016/0005-2744(80)90120-5. PMID 7370276.

See also

External links

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