NLRC3

NLR family, CARD domain containing 3
Identifiers
Symbols	NLRC3 ; CLR16.2; NOD3
External IDs	OMIM: 615648 MGI: 2444070 HomoloGene: 18720 IUPHAR: 1764 GeneCards: NLRC3 Gene
Gene ontology Molecular function • molecular_function • ATP binding Cellular component • cytoplasm Biological process • I-kappaB kinase/NF-kappaB signaling • regulation of protein ubiquitination • negative regulation of NF-kappaB transcription factor activity • response to lipopolysaccharide • negative regulation of interleukin-6 production • negative regulation of tumor necrosis factor production • T cell activation • negative regulation of I-kappaB kinase/NF-kappaB signaling Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	197358	268857
Ensembl	ENSG00000167984	ENSMUSG00000049871
UniProt	Q7RTR2	Q5DU56
RefSeq (mRNA)	NM_178844	NM_001081280
RefSeq (protein)	NP_849172	NP_001074749
Location (UCSC)	Chr 16: 3.54 – 3.58 Mb	Chr 16: 3.95 – 3.98 Mb
PubMed search

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system.^[1] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.^[2]

References

1. Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.
2. Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.