NLRP6

NLR family, pyrin domain containing 6
Identifiers
Symbols	NLRP6 ; AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; PAN3; PYPAF5
External IDs	OMIM: 609650 MGI: 2141990 HomoloGene: 15881 IUPHAR: 1773 GeneCards: NLRP6 Gene
Gene ontology Molecular function • vasopressin receptor activity • ATP binding Cellular component • cytoplasm • plasma membrane • nuclear membrane Biological process • negative regulation of inflammatory response to antigenic stimulus • G-protein coupled receptor signaling pathway • response to bacterium • regulation of autophagy • negative regulation of toll-like receptor signaling pathway • wound healing • negative regulation of I-kappaB kinase/NF-kappaB signaling • regulation of inflammatory response • regulation of mucus secretion • negative regulation of ERK1 and ERK2 cascade Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	171389	101613
Ensembl	ENSG00000174885	ENSMUSG00000038745
UniProt	P59044	Q91WS2
RefSeq (mRNA)	NM_001276700	NM_001081389
RefSeq (protein)	NP_001263629	NP_598707
Location (UCSC)	Chr 11: 0.28 – 0.29 Mb	Chr 7: 140.92 – 140.93 Mb
PubMed search

NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.^[1]

References

1. Grenier JM, Wang L, Manji GA, et al. (October 2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869.

Further reading

• Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
• Albrecht M, Domingues FS, Schreiber S, Lengauer T (2003). "Identification of mammalian orthologs associates PYPAF5 with distinct functional roles". FEBS Lett. 538 (1–3): 173–7. doi:10.1016/S0014-5793(03)00161-3. PMID 12633874.
• Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.
• Wang L, Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J. Biol. Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.