NLRP8
| NLR family, pyrin domain containing 8 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | NLRP8 ; CLR19.2; NALP8; NOD16; PAN4 | ||||||||||||
| External IDs | OMIM: 609659 HomoloGene: 82360 IUPHAR: 1775 GeneCards: NLRP8 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 126205 | n/a | |||||||||||
| Ensembl | ENSG00000179709 | n/a | |||||||||||
| UniProt | Q86W28 | n/a | |||||||||||
| RefSeq (mRNA) | NM_176811 | n/a | |||||||||||
| RefSeq (protein) | NP_789781 | n/a | |||||||||||
| Location (UCSC) |
Chr 19: 55.95 – 55.99 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
NLRP8, short for NOD-like receptor family pyrin domain containing 8, is an intracellular protein that is expressed in the ovaries, testes, and preimplantation embryos of mammals.[1][2] It is also known as NALP8, NOD16, PAN4, and CLR19.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.
References
- ↑ Ponsuksili S, Brunner RM, Goldammer T, et al. (March 2006). "Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos". Biol. Reprod. 74 (3): 577–84. doi:10.1095/biolreprod.105.045096. PMID 16339045.
- ↑ Tian X, Pascal G, Monget P (2009). "Evolution and functional divergence of NLRP genes in mammalian reproductive systems". BMC Evol. Biol. 9: 202. doi:10.1186/1471-2148-9-202. PMC 2735741. PMID 19682372.
Further reading
- Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
- Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis.". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759.
- Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation.". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.
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